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Titolo:
Vagus nerve stimulation in children with refractory seizures associated with Lennox-Gastaut syndrome
Autore:
Frost, M; Gates, J; Helmers, SL; Wheless, JW; Levisohn, P; Tardo, C; Conry, JA;
Indirizzi:
United Hosp, Minnesota Epilepsy Grp PA, St Paul, MN USA United Hosp St Paul MN USA p, Minnesota Epilepsy Grp PA, St Paul, MN USA Childrens Hosp, Minnesota Epilepsy Grp PA, St Paul, MN USA Childrens HospSt Paul MN USA Minnesota Epilepsy Grp PA, St Paul, MN USA Emory Univ, Atlanta, GA 30322 USA Emory Univ Atlanta GA USA 30322Emory Univ, Atlanta, GA 30322 USA Harvard Univ, Childrens Hosp, Sch Med, Dept Neurol,Div Epilepsy & Clin Neurophysiol, Boston, MA 02115 USA Harvard Univ Boston MA USA 02115 Clin Neurophysiol, Boston, MA 02115 USA Univ Texas, Texas Comprehens Epilepsy Program, Houston, TX USA Univ TexasHouston TX USA s Comprehens Epilepsy Program, Houston, TX USA Childrens Hosp, Denver, CO 80218 USA Childrens Hosp Denver CO USA 80218Childrens Hosp, Denver, CO 80218 USA Univ Colorado, Hlth Sci Ctr, Dept Pediat & Neurol, Denver, CO USA Univ Colorado Denver CO USA ci Ctr, Dept Pediat & Neurol, Denver, CO USA Louisiana State Univ, Comprehens Epilepsy Ctr, New Orleans, LA 70112 USA Louisiana State Univ New Orleans LA USA 70112 , New Orleans, LA 70112 USA Childrens Natl Med Ctr, Dept Neurol, Washington, DC 20010 USA Childrens Natl Med Ctr Washington DC USA 20010 , Washington, DC 20010 USA
Titolo Testata:
EPILEPSIA
fascicolo: 9, volume: 42, anno: 2001,
pagine: 1148 - 1152
SICI:
0013-9580(200109)42:9<1148:VNSICW>2.0.ZU;2-S
Fonte:
ISI
Lingua:
ENG
Soggetto:
CORPUS CALLOSOTOMY; ANTIEPILEPTIC DRUGS; EPILEPSY; THERAPY; LAMOTRIGINE; FELBAMATE;
Keywords:
Lennox-Gastaut; intractable epilepsy; vagus nerve stimulation;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
28
Recensione:
Indirizzi per estratti:
Indirizzo: Frost, M Minnesota Epilepsy Grp PA, 310 N Smith Ave 300, St Paul, MN 55102USA Minnesota Epilepsy Grp PA 310 N Smith Ave 300 St Paul MN USA 55102
Citazione:
M. Frost et al., "Vagus nerve stimulation in children with refractory seizures associated with Lennox-Gastaut syndrome", EPILEPSIA, 42(9), 2001, pp. 1148-1152

Abstract

Purpose: Vagus nerve stimulation (VNS) is approved for use for refractory partial seizures. Nevertheless, information regarding VNS therapy for special populations, including Lennox-Gastaut syndrome (LGS) is limited. We discuss the effectiveness, tolerability, and safety of VNS therapy in patients with LGS. Methods: A six-center, retrospective study evaluated the effectiveness of VNS therapy in patients with LGS at 3 and 6 months and compared preimplant and postimplant seizure frequency. Adverse effects and quality of life (QOL) were included as secondary measures. Results: Fifty patients, median age 13 years, with medically refractory epilepsy, were implanted. Median age at onset of seizures was 1.4 years, and a median of nine anticonvulsants (AEDs) had been tried before implantation. Data-collection forms were designed for retrospectively gathering data on each patient's preimplant history, Seizures, implants, device settings, QOL, and adverse events. Median reductions in total seizures were 42% at 1 month, 58.2% at 3 months, and 57.9% at 6 months. The most common adverse events reported were voice alteration and coughing during stimulation. Other uncommon adverse events included increased drooling and behavioral changes. Investigators noted that QOL had improved for some patients in the study. Conclusions: VNS is an effective treatment for medically refractory epilepsy in LGS. This treatment is well tolerated, safe, and may improve QOL.

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Documento generato il 10/07/20 alle ore 11:57:11