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Titolo:
Peroxynitrite scavenging of flavonoids: structure activity relationship
Autore:
Heijnen, CGM; Haenen, GRMM; Vekemans, JAJM; Bast, A;
Indirizzi:
Univ Maastricht, Fac Med, Dept Pharmacol & Toxicol, NL-6200 MD Maastricht,Netherlands Univ Maastricht Maastricht Netherlands NL-6200 MD Maastricht,Netherlands Eindhoven Univ Technol, Lab Macromol & Organ Chem, NL-5600 MB Eindhoven, Netherlands Eindhoven Univ Technol Eindhoven Netherlands NL-5600 MB ven, Netherlands
Titolo Testata:
ENVIRONMENTAL TOXICOLOGY AND PHARMACOLOGY
fascicolo: 4, volume: 10, anno: 2001,
pagine: 199 - 206
SICI:
1382-6689(200109)10:4<199:PSOFSA>2.0.ZU;2-5
Fonte:
ISI
Lingua:
ENG
Soggetto:
ANTIOXIDANT ACTIVITY; SUPEROXIDE-DISMUTASE; MEDIATED OXIDATION; NITRATION; TEA;
Keywords:
flavonoid; phenolic compounds; structure activity relationships; peroxynitrite scavenging; antioxidant; Hammett sigma;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
26
Recensione:
Indirizzi per estratti:
Indirizzo: Heijnen, CGM Univ Maastricht, Fac Med, Dept Pharmacol & Toxicol, POB 616, NL-6200 MD Maastricht, Netherlands Univ Maastricht POB 616 Maastricht Netherlands NL-6200 MD ds
Citazione:
C.G.M. Heijnen et al., "Peroxynitrite scavenging of flavonoids: structure activity relationship", ENV TOX PH, 10(4), 2001, pp. 199-206

Abstract

Peroxynitrite can oxidise and nitrosylate biomolecules and is associated with several diseases. The peroxynitrite scavenging of substituted phenols and several flavonoids was studied. The activity of phenol (poor scavenger) is positively influenced by electron donating substituents. A good correlation was found between the peroxynitrite scavenging activity of the substituted phenols and the Hammett sigma or the E-HOMO. Flavonols containing a catechol group (3'- and 4'-OH) in ring B (rutin and monohydroxyethyl rutoside)or an AC-ring with three OH groups (3-, 5- and 7-OH) were potent scavengers. Evidence has been produced that in the AC-ring the 3-OH group was the reactive centre and that the reactivity of this group was positively influenced by electron donating groups at the 5 and/or 7 position (galangin, kaempferol, trihydroxyethyl quercetin). (C) 2001 Elsevier Science B.V. All rightsreserved.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 03/06/20 alle ore 08:25:27