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Titolo:
Antioxidants in critical care medicine
Autore:
Coleman, NA;
Indirizzi:
N Staffordshire NHS Trust, City Gen Hosp, Dept Intens Care, Stoke On TrentST4 7PS, Staffs, England N Staffordshire NHS Trust Stoke On Trent Staffs England ST4 7PS , England
Titolo Testata:
ENVIRONMENTAL TOXICOLOGY AND PHARMACOLOGY
fascicolo: 4, volume: 10, anno: 2001,
pagine: 183 - 188
SICI:
1382-6689(200109)10:4<183:AICCM>2.0.ZU;2-I
Fonte:
ISI
Lingua:
ENG
Soggetto:
ANEURYSMAL SUBARACHNOID HEMORRHAGE; RESPIRATORY-DISTRESS SYNDROME; ISCHEMIA-REPERFUSION INJURY; VEHICLE-CONTROLLED TRIAL; DOSE TIRILAZAD MESYLATE; SPINAL-CORD INJURY; DOUBLE-BLIND; N-ACETYLCYSTEINE; ILL PATIENTS; 21-AMINOSTEROID U74006F;
Keywords:
antioxidant; acute respiratory distress syndrome; selenium;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
38
Recensione:
Indirizzi per estratti:
Indirizzo: Coleman, NA N Staffordshire NHS Trust, City Gen Hosp, Dept Intens Care, Newcastle Rd, Stoke On Trent ST4 7PS, Staffs, England N Staffordshire NHS Trust Newcastle Rd Stoke On Trent Staffs England ST4 7PS
Citazione:
N.A. Coleman, "Antioxidants in critical care medicine", ENV TOX PH, 10(4), 2001, pp. 183-188

Abstract

Critically ill patients in the intensive care unit (ICU) present with a variety of different pathologies, and mortality is high despite extensive multi-organ supportive treatment. Reactive oxygen species (ROS) are believed to play a pivotal role in the pathophysiology of organ dysfunction in the ICU. In particular, the role of ROS as a final common pathway of cell damage has been increasingly emphasised in the adult respiratory distress syndrome(ARDS), in central nervous system traumatic and hypoxic states, and as a cause of ischaemic neurological deficits after subarachnoid haemorrhage. Measurement of total antioxidant status (TAS) has shown improved survival of patients with high TAS and poorer outcomes for those with lower values. Attempts to supplement endogenous antioxidant defences have not demonstrated clear benefits in randomised clinical trials, and the use of free radical scavenging agents have had similar mixed results. Considering the wide variation in the nature and severity of illness in the intensive care population, it is not surprising that clear evidence of the efficacy of antioxidant therapies in improving survival has not been clearly demonstrated. However, single component therapies for complex pathophysiological processes are rarely successful, and the role of antioxidants in the critically ill should be thought of as only part of a rational and logical therapeutic approach. (C)2001 Elsevier Science B.V. All rights reserved.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 19/01/20 alle ore 06:12:33