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Titolo:
Ascorbic acid in the 21 st century - more than a simple antioxidant
Autore:
Griffiths, HR; Lunec, J;
Indirizzi:
Aston Univ, Pharmaceut Sci Res Inst, Birmingham B4 7ET, W Midlands, England Aston Univ Birmingham W Midlands England B4 7ET 7ET, W Midlands, England Univ Leicester, Leicester Royal Infirm, Div Chem Pathol, Leicester LE2 7LX, Leics, England Univ Leicester Leicester Leics England LE2 7LX er LE2 7LX, Leics, England
Titolo Testata:
ENVIRONMENTAL TOXICOLOGY AND PHARMACOLOGY
fascicolo: 4, volume: 10, anno: 2001,
pagine: 173 - 182
SICI:
1382-6689(200109)10:4<173:AAIT2S>2.0.ZU;2-M
Fonte:
ISI
Lingua:
ENG
Soggetto:
SMOOTH-MUSCLE CELLS; VITAMIN-C SUPPLEMENTATION; OXIDATIVE DNA-DAMAGE; PROTEIN OXIDATION; HEALTHY-VOLUNTEERS; ENDOTHELIAL-CELLS; SKIN FIBROBLASTS; HUMAN LENSES; GLYCATION; PRODUCTS;
Keywords:
ascorbic acid; oxidative DNA damage and repair; cancer; protein oxidation; gene expressions cardiovascular disease;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
40
Recensione:
Indirizzi per estratti:
Indirizzo: Griffiths, HR Aston Univ, Pharmaceut Sci Res Inst, Aston Triangle, Birmingham B4 7ET, W Midlands, England Aston Univ Aston Triangle Birmingham W Midlands England B4 7ET
Citazione:
H.R. Griffiths e J. Lunec, "Ascorbic acid in the 21 st century - more than a simple antioxidant", ENV TOX PH, 10(4), 2001, pp. 173-182

Abstract

Ascorbic acid (AA) is an essential micronutrient for man, with many biological roles. It is a powerful antioxidant both directly via scavenging of reactive oxygen species and indirectly through regeneration of other antioxidant systems. Paradoxically, under certain conditions (low concentration in vitro, presence of metal ions) it can exert a pro-oxidant effect, increasing oxidative damage to lipids, DNA and protein. Herein, the effects of vitamin C both in vitro and in vivo are addressed in terms of modulation of oxidative DNA damage, gene expression and protein oxidation. The view of AA as a simple scavenger is outdated, where the arrival of new bioinformatic techniques, heralds a new dawning in our understanding of ascorbate as a potential direct or indirect modulator of gene expression. (C) 2001 Elsevier Science B.V. All rights reserved.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 04/07/20 alle ore 20:41:56