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Titolo:
Should we recommend the therapeutical use of vitamin E in diabetic patients?
Autore:
Paolisso, G; Barbieri, M; Rizzo, MR; Manzella, D;
Indirizzi:
Univ Naples 2, Dept Geriatr Med & Metab Dis, I-80138 Naples, Italy Univ Naples 2 Naples Italy I-80138 ed & Metab Dis, I-80138 Naples, Italy
Titolo Testata:
ENVIRONMENTAL TOXICOLOGY AND PHARMACOLOGY
fascicolo: 4, volume: 10, anno: 2001,
pagine: 159 - 165
SICI:
1382-6689(200109)10:4<159:SWRTTU>2.0.ZU;2-7
Fonte:
ISI
Lingua:
ENG
Soggetto:
CORONARY HEART-DISEASE; ALPHA-TOCOPHEROL SUPPLEMENTATION; OXIDATIVE STRESS; INSULIN ACTION; LIPOPROTEIN OXIDATION; BETA-CAROTENE; E CONSUMPTION; ANTIOXIDANT; RATS; STREPTOZOTOCIN;
Keywords:
vitamin E; coronary heart diseases; diabetes; endothelial function; metabolic control;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
43
Recensione:
Indirizzi per estratti:
Indirizzo: Paolisso, G Univ Naples 2, Dept Geriatr Med & Metab Dis, Piazza Miraglia 2, I-80138 Naples, Italy Univ Naples 2 Piazza Miraglia 2 Naples Italy I-80138 s, Italy
Citazione:
G. Paolisso et al., "Should we recommend the therapeutical use of vitamin E in diabetic patients?", ENV TOX PH, 10(4), 2001, pp. 159-165

Abstract

The therapeutic application of vitamin E was initially restricted to thrombocytopenic purpura and later extended to coronary artery diseases and peripheral vascular arteriosclerosis due to the potency of its effects. Severalrecent studies have pointed out that vitamin E supplementation is useful for reducing low-density lipoprotein oxidation and thus might be protective towards coronary heart disease. Such data has been confirmed in many in vitro data, while in vivo results of reports from epidemiological studies are much more controversial. More consistent is the evidence showing vitamin E to improve endothelial function especially in diabetic patients. Finally, chronic vitamin E has been demonstrated to improve the metabolic control in diabetic patients. Whether chronic vitamin E administration at pharmacological doses and for long time, is safe is still debated. A sure response to such a query will open the possibility for recommending vitamin E as a therapeutic agent in diabetic patients. (C) 2001 Elsevier Science B.V. All rights reserved.

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Documento generato il 04/06/20 alle ore 01:45:54