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Titolo:
The biochemistry of selenium and the glutathione system
Autore:
Arteel, GE; Sies, H;
Indirizzi:
Univ Dusseldorf, Inst Physiol Chem 1, D-40001 Dusseldorf, Germany Univ Dusseldorf Dusseldorf Germany D-40001 , D-40001 Dusseldorf, Germany Univ N Carolina, Dept Pharmacol, Hepatobiol & Toxicol Lab, Chapel Hill, NC27599 USA Univ N Carolina Chapel Hill NC USA 27599 ol Lab, Chapel Hill, NC27599 USA
Titolo Testata:
ENVIRONMENTAL TOXICOLOGY AND PHARMACOLOGY
fascicolo: 4, volume: 10, anno: 2001,
pagine: 153 - 158
SICI:
1382-6689(200109)10:4<153:TBOSAT>2.0.ZU;2-T
Fonte:
ISI
Lingua:
ENG
Soggetto:
BLIND CLINICAL-TRIAL; SELENOPROTEIN-P; THIOREDOXIN REDUCTASE; HUMAN PLASMA; OXIDATIVE STRESS; PEROXYNITRITE REDUCTASE; NITRIC-OXIDE; EBSELEN; PEROXIDASE; SELENOMETHIONINE;
Keywords:
glutathione; selenium; selenoproteins; glutathione peroxidase; peroxynitrite; antioxidant;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
66
Recensione:
Indirizzi per estratti:
Indirizzo: Sies, H Univ Dusseldorf, Inst Physiol Chem 1, Postfach 101007, D-40001 Dusseldorf,Germany Univ Dusseldorf Postfach 101007 Dusseldorf Germany D-40001ermany
Citazione:
G.E. Arteel e H. Sies, "The biochemistry of selenium and the glutathione system", ENV TOX PH, 10(4), 2001, pp. 153-158

Abstract

In the context of defense against pro-oxidants, selenium and the glutathione (GSH) system play key functions. Major roles of GSH include direct interception of pro-oxidants, as well as a reduction of other antioxidants from their oxidized forms. Furthermore, GSH has ancillary functions, such as metabolism, cell signaling, and protein interactions, that can also mediate defense against oxidants. Protection by selenium in the mammalian cell is mediated by selenol-aminoacids, either as selenocysteine or selenomethionine. The active site of the potent glutathione peroxidases (GPx) contains selenocysteine residues. Furthermore, other selenoproteins (e.g. selenoprotein P and thioredoxin reductase) also have been shown to possess antioxidant properties. Synthetic organoselenium compounds (e.g. ebselen) have also shown promise as pharmacologic antioxidants in in vivo models of tissue damage dueto oxidative stress. The specific function of selenoproteins and organoselenium compounds in defense against peroxynitrite, by reduction of this potent oxidizing and nitrating species to nitrite, is also discussed. (C) 2001 Elsevier Science B.V. All rights reserved.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 25/01/20 alle ore 04:15:33