Catalogo Articoli (Spogli Riviste)

OPAC HELP

Titolo:
Effects of endocrine disruptors on prosobranch snails (Mollusca : Gastropoda) in the laboratory. Part III: Cyproterone acetate and vinclozolin as antiandrogens
Autore:
Tillmann, M; Schulte-Oehlmann, U; Duft, M; Markert, B; Oehlmann, J;
Indirizzi:
Int Hsch Inst Zittau, Lehrstuhl Umweltverfahrenstech, Fachgrp Human & Okotoxikol, D-02763 Zittau, Germany Int Hsch Inst Zittau Zittau Germany D-02763 kol, D-02763 Zittau, Germany
Titolo Testata:
ECOTOXICOLOGY
fascicolo: 6, volume: 10, anno: 2001,
pagine: 373 - 388
SICI:
0963-9292(2001)10:6<373:EOEDOP>2.0.ZU;2-J
Fonte:
ISI
Lingua:
ENG
Soggetto:
MORPHOLOGICAL EXPRESSION; TRIBUTYLTIN POLLUTION; FUNGICIDE VINCLOZOLIN; LITTORINA-LITTOREA; NUCELLA-LAPILLUS; BISPHENOL-A; MALE-RAT; INDICATOR; IMPOSEX; CONTAMINATION;
Keywords:
endocrine disruptors; antiandrogens; cyproterone acetate; vinclozolin; snails;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Agriculture,Biology & Environmental Sciences
Citazioni:
59
Recensione:
Indirizzi per estratti:
Indirizzo: Oehlmann, J Univ Frankfurt, Inst Zool, Abt Okol, Siesmayerstr 70, D-60054 Frankfurt, Germany Univ Frankfurt Siesmayerstr 70 Frankfurt Germany D-60054 many
Citazione:
M. Tillmann et al., "Effects of endocrine disruptors on prosobranch snails (Mollusca : Gastropoda) in the laboratory. Part III: Cyproterone acetate and vinclozolin as antiandrogens", ECOTOXICOL, 10(6), 2001, pp. 373-388

Abstract

The effects of suspected endocrine disrupting chemicals on freshwater and marine prosobranch species were analysed in laboratory experiments. In thislast of three publications, the responses of the fresh water snail Marisa cornuarietis and of two marine prosobranchs (Nucella lapillus, Nassarius (Hinia) reticulatus) to the antiandrogenic model compounds cyproterone acetate (CPA) and vinclozolin (VZ) are presented. The snails were exposed to nominal CPA concentrations of 1.25 mg/L alone and simultaneously to a potent synthetic estrogen (ethinylestradiol), androgen (methyltestosterone) or an indirectly acting xeno-androgen (tributyltin) in experiments with adult specimens and in a life cycle test for 12 months. Marisa and Nucella were furthermore exposed to nominal concentrations of 0.03-1.0 mug VZ/L for up to 5 months. The antiandrogens induced a number of biological responses in all three species. The length of the penis and of accessory male sex organs (e.g.,penis sheath, prostate) were significantly reduced. For Marisa, this effect occurred only in sexually immature specimens and was reversible as the males attained puberty. Typical androgen-mediated responses (imposex development, delayed spermatogenesis, tubulus necrosis of the testis with orchitis and Leydig cell hyperplasia) were partially or totally suppressed by a simultaneous administration of CPA. In the two marine species even adult, sexually mature males responded to antiandrogens with a reduction of the male sex organs and an advancement of the sexual repose phase. The results for CPAand VZ are compared with the effects of an exposure to xeno-estrogens (bisphenol A, octylphenol) and xeno-androgens (triphenyltin, tributyltin) in the same species. Each group of endocrine disruptors induces a characteristicset of toxicological effects in prosobranch snails which can be used as endpoints in an organismic invertebrate test for the identification of endocrine mimetic test compounds. Estrogens cause primarily an induction of superfemales resulting in an increased female mortality by the enhancement of spawning mass and egg production. The main effects of androgens are a virilization of females by imposex development and a marked decrease of the fecundity. Compared with estrogens and androgens, the antiandrogen responses seemto be less drastic and might have-in contrast to the two other disruptor classes-no biologically significant effects at the population level.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 23/01/21 alle ore 01:53:21