Catalogo Articoli (Spogli Riviste)

OPAC HELP

Titolo:
Comparative anti-staphylococcal effects of gemifloxacin and trovafloxacin in an in vitro dynamic model in terms of AUC/MIC and dose relationships
Autore:
Zinner, SH; Vostrov, SN; Lubenko, IY; Portnoy, YA; Cornaglia, G; Firsov, AA;
Indirizzi:
LekBioTech, Ctr Sci & Technol, Dept Pharmacokinet, Moscow 119992, Russia LekBioTech Moscow Russia 119992 ept Pharmacokinet, Moscow 119992, Russia Mt Auburn Hosp, Dept Med, Cambridge, MA USA Mt Auburn Hosp Cambridge MA USA Auburn Hosp, Dept Med, Cambridge, MA USA Dept Pharmacokinet & Pharmacodynam, Moscow 119992, Russia Dept Pharmacokinet & Pharmacodynam Moscow Russia 119992 w 119992, Russia Univ Verona, Inst Microbiol, I-37100 Verona, Italy Univ Verona Verona Italy I-37100 , Inst Microbiol, I-37100 Verona, Italy
Titolo Testata:
DIAGNOSTIC MICROBIOLOGY AND INFECTIOUS DISEASE
fascicolo: 4, volume: 40, anno: 2001,
pagine: 167 - 171
SICI:
0732-8893(200108)40:4<167:CAEOGA>2.0.ZU;2-O
Fonte:
ISI
Lingua:
ENG
Soggetto:
CIPROFLOXACIN; PREDICTION; PHARMACODYNAMICS; PHARMACOKINETICS; BREAKPOINTS; CP-99,219;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
10
Recensione:
Indirizzi per estratti:
Indirizzo: Firsov, AA LekBioTech, Ctr Sci & Technol, Dept Pharmacokinet, 11 Bolshaya Pirogovskaya St, Moscow 119992, Russia LekBioTech 11 Bolshaya Pirogovskaya St Moscow Russia 119992 ia
Citazione:
S.H. Zinner et al., "Comparative anti-staphylococcal effects of gemifloxacin and trovafloxacin in an in vitro dynamic model in terms of AUC/MIC and dose relationships", DIAG MICR I, 40(4), 2001, pp. 167-171

Abstract

To compare the antimicrobial effects of gemifloxacin and trovafloxacin on Staphylococcus aureus, their pharmacodynamics were studied in an in vitro dynamic model. A series of pharmacokinetic profiles of gemifloxacin and trovafloxacin with half-lives of 7.4 and 9.2 h, respectively, were simulated invitro over an eightfold range of area under the curve (AUC)-to-MIC ratio, from 58 to 466 h. The relationships observed between the intensity of antimicrobial effect (I-E) and log AUC/MIC were linear, species- and strain-independent and were distinct (not superimposed) for both gemifloxacin and trovafloxacin (r(2) = 0.99 in both cases). At AUC/MlCs > 100 It, trovafloxacin had greater effects than gemifloxacin. For example, at an AUC/MIC of 250 h,the antimicrobial effect of trovafloxacin was 17% higher than gemifloxacin. However, due to its higher intrinsic activity, gemifloxacin may be as efficient as trovafloxacin at their clinical doses (320 and 200 mg. respectively): the I(E)s on a hypothetical strain of S. aureus with gemifloxacin's and trovafloxacin's MICs corresponding to the MlC(50)s were similar-290 and 310 (log CFU/mL)xh, respectively. This analysis suggests that both AUC/MIC and close relationships of the antimicrobial effect are needed for comprehensive comparisons of fluoroquinolone pharmacodynamics. (C) 2001 Elsevier Science Inc. All rights reserved.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 27/10/20 alle ore 10:14:43