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Titolo:
Serous fluid cytology as a means of detecting hemophagocytosis in Epstein-Barr virus-induced autoimmune hemolytic anemia
Autore:
Zaharopoulos, P;
Indirizzi:
Univ Texas, Med Branch, Dept Pathol, Galveston, TX 77555 USA Univ Texas Galveston TX USA 77555 h, Dept Pathol, Galveston, TX 77555 USA
Titolo Testata:
DIAGNOSTIC CYTOPATHOLOGY
fascicolo: 4, volume: 25, anno: 2001,
pagine: 248 - 252
SICI:
8755-1039(200110)25:4<248:SFCAAM>2.0.ZU;2-K
Fonte:
ISI
Lingua:
ENG
Soggetto:
ROSAI-DORFMAN SYNDROME; T-CELL LYMPHOMA; REACTIVE HEMOPHAGOCYTOSIS; ASPIRATION CYTOLOGY; SINUS HISTIOCYTOSIS; INFECTION; LYMPHOHISTIOCYTOSIS;
Keywords:
hemophagocytic syndrome; autoimmune hemolytic anemia; Epstein-Barr virus infection; pleural fluid cytology; bone marrow viral effect;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Citazioni:
26
Recensione:
Indirizzi per estratti:
Indirizzo: Zaharopoulos, P Univ Texas, Med Branch, Dept Pathol, Galveston, TX 77555 USA Univ Texas Galveston TX USA 77555 Galveston, TX 77555 USA
Citazione:
P. Zaharopoulos, "Serous fluid cytology as a means of detecting hemophagocytosis in Epstein-Barr virus-induced autoimmune hemolytic anemia", DIAGN CYTOP, 25(4), 2001, pp. 248-252

Abstract

The case of, a 22-yr-old incite who after a brief febrile episode developed autoimmune hemolytic anemia and right pulmonary infiltrate with pleural effusion is presented. Cytologic examination on of the pleural fluid revealed lymphocytosis and hemophagocytosis, primarily of red blood cells (RBCs) by mature histiocytes. There was accompanying splenomegaly, laboratory evidence of hepatic dysfunction, and retroperitoneal lymphadenopathy. Besides profound reduction of red blood cells in the peripheral blood, there was reduction of lymphocytes and platelets. As a neoplastic process was rated out by bone marrow and pleural biopsies, the disease was considered to be virus-induced and was halted and progressively regressed with early institution of vigorous antiflammatory therapy with adrenocortical steroids. Upon reviewing the case, examination of the bone marrow biopsy disclosed limited hemophagocytosis of RBCs and lymphocytes by histiocytes and considerable viral cytopathic effect on hematopoietic cells (red and white cell precursors and megakaryocytes), which by appropriate immunolabelling was identified as induced by Epstein-Barr virus. A virus-related acquired hemophagocytic syndrome in its early stages was probably present, yet an undesirable clinical outcome was averted by early institution of vigorous steroid therapy. The needto recognize early hemophagocytic changes in cytologic specimens for earlyinstitution of appropriate therapy is emphasized. The possibility of erythrophagocytosis, also manifested during the course of an autoimmune hemolytic process and unrelated to hemophagocytic syndrome, is discussed. (C) 2001 Wiley-Liss, Inc.

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Documento generato il 03/04/20 alle ore 07:35:54