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Titolo:
T-cell subtypes in bronchoalveolar lavage fluid and in peripheral blood from patients with primary lung cancer
Autore:
Domagala-Kulawik, J; Hoser, G; Droszcz, P; Kawiak, J; Droszcz, W; Chazan, R;
Indirizzi:
Warsaw Acad Med & Hosp, Dept Pneumonol & Allergol, PL-02097 Warsaw, PolandWarsaw Acad Med & Hosp Warsaw Poland PL-02097 l, PL-02097 Warsaw, Poland
Titolo Testata:
DIAGNOSTIC CYTOPATHOLOGY
fascicolo: 4, volume: 25, anno: 2001,
pagine: 208 - 213
SICI:
8755-1039(200110)25:4<208:TSIBLF>2.0.ZU;2-U
Fonte:
ISI
Lingua:
ENG
Soggetto:
TUMOR-INFILTRATING LYMPHOCYTES; BRONCHOGENIC-CARCINOMA; MONOCLONAL-ANTIBODIES; CIGARETTE-SMOKING; FLOW-CYTOMETRY; SUBSETS; SMOKERS; INTERLEUKIN-2; MACROPHAGES; TISSUES;
Keywords:
lung cancer; lymphocytes; bronchoalveolar lavage; flow cytometry;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Citazioni:
27
Recensione:
Indirizzi per estratti:
Indirizzo: Domagala-Kulawik, J Warsaw Acad Med & Hosp, Dept Pneumonol & Allergol, Ul Banache 1A, PL-02097Warsaw, Poland Warsaw Acad Med & Hosp Ul Banache 1A Warsaw Poland PL-02097
Citazione:
J. Domagala-Kulawik et al., "T-cell subtypes in bronchoalveolar lavage fluid and in peripheral blood from patients with primary lung cancer", DIAGN CYTOP, 25(4), 2001, pp. 208-213

Abstract

The changes in local immunology play an important role in lung cancer development. Ve used bronchoalveolar lavage fluid (BALF) and peripheral blood (PB) for the analysis of cell profiles in patients with primary lung cancer. Twenty-one patients with confirmed primary lung cancer and 13 healthy volunteers were investigated. All persons were smokers. The analysis of T-cell subsets was performed with a flow cytometry method and with the following antibodies: anti CD3, CD4, CD8, CD16, CD25, CD-45, CD56, and HLA-DR. We found differences in the proportion of lymphocytes between BALF and PB, and a higher proportion of T cells and a lower proportion of B and natural-killer (NK) cells in BALF. There was a significant difference in the proportion ofT-cytotoxic/suppressor lymphocytes, which was elevated in the BALF of patients and decreased in patients' PB. The T-helper:cytotoxic/suppressor (Th:Tc/s) ratio was significantly lower in the BALF of patients. These changes were visible in patients with a small cell type. The percentage of T cells with the a chain of receptor to IL-2 (IL-R) was lower in the BALF of patients than in the control group. Our observations reflect local changes in lungenvironment in patients affected with lung cancer.(C) 2001 Wiley-Liss, Inc.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 25/01/20 alle ore 16:05:11