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Titolo:
Neuronal regeneration in the cerebellum of adult teleost fish, Apteronotusleptorhynchus: guidance of migrating young cells by radial glia
Autore:
Clint, SC; Zupanc, GKH;
Indirizzi:
Univ Manchester, Sch Biol Sci, Manchester M13 9PT, Lancs, England Univ Manchester Manchester Lancs England M13 9PT M13 9PT, Lancs, England
Titolo Testata:
DEVELOPMENTAL BRAIN RESEARCH
fascicolo: 1, volume: 130, anno: 2001,
pagine: 15 - 23
SICI:
0165-3806(20010923)130:1<15:NRITCO>2.0.ZU;2-V
Fonte:
ISI
Lingua:
ENG
Soggetto:
FIBRILLARY ACIDIC PROTEIN; CENTRAL POSTERIOR/PREPACEMAKER NUCLEUS; FETAL MONKEY NEOCORTEX; CENTRAL-NERVOUS-SYSTEM; GYMNOTIFORM FISH; DENTATE GYRUS; SPINAL-CORD; POSTEMBRYONIC DEVELOPMENT; OPTIC TECTUM; AVIAN BRAIN;
Keywords:
neuronal regeneration; adult neurogenesis; migration; radial glia; cerebellum; teleost fish;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
67
Recensione:
Indirizzi per estratti:
Indirizzo: Zupanc, GKH Univ Manchester, Sch Biol Sci, 3-614 Stopford Bldg,Oxford Rd, Manchester M13 9PT, Lancs, England Univ Manchester 3-614 Stopford Bldg,Oxford Rd Manchester Lancs England M13 9PT
Citazione:
S.C. Clint e G.K.H. Zupanc, "Neuronal regeneration in the cerebellum of adult teleost fish, Apteronotusleptorhynchus: guidance of migrating young cells by radial glia", DEV BRAIN R, 130(1), 2001, pp. 15-23

Abstract

In contrast to mammals, adult fish exhibit an enormous potential to replace injured brain neurons by newly generated ones. In the present study, the role of radial glia, identified by immunostaining against fibrillary acidicprotein (GFAP), was examined in this process of neuronal regeneration. Approximately 8 days after application of a mechanical lesion to the corpus cerebelli in the teleost fish Apteronotus leptorhynchus, the areal density ofradial glial fibers increased markedly in the ipsilateral dorsal molecularlayer compared to shorter survival times, or to the densities found in theintact brain or in the hemisphere contralateral to the lesion. This density remained elevated throughout the time period of up to 100 days examined. The increase in fiber density was followed approximately 2 days later by a rise in the areal density of young cells, characterized by labeling with the nuclear dye DAPI, in the ipsilateral dorsal molecular layer. Based on this remarkable spatio-temporal correlation, and the frequently observed closeapposition of elongated young cells to radial glial fibers, we hypothesizethat radial glia play an important role in the guidance of migrating youngcells from their proliferation zones to the site of lesion where regeneration takes place. (C) 2001 Elsevier Science B.V. All rights reserved.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 19/09/20 alle ore 08:08:33