Catalogo Articoli (Spogli Riviste)

OPAC HELP

Titolo:
X-Serrate-1 is involved in primary neurogenesis in Xenopus laevis in a complementary manner with X-Delta-1
Autore:
Kiyota, T; Jono, H; Kuriyama, S; Hasegawa, K; Miyatani, S; Kinoshita, T;
Indirizzi:
Kwansei Gakuin Univ, Fac Sci, Nishinomiya, Hyogo 6628501, Japan Kwansei Gakuin Univ Nishinomiya Hyogo Japan 6628501 Hyogo 6628501, Japan RIKEN, Ikawa Special Lab, Wako, Saitama 3510198, Japan RIKEN Wako SaitamaJapan 3510198 pecial Lab, Wako, Saitama 3510198, Japan
Titolo Testata:
DEVELOPMENT GENES AND EVOLUTION
fascicolo: 8-9, volume: 211, anno: 2001,
pagine: 367 - 376
SICI:
0949-944X(200109)211:8-9<367:XIIIPN>2.0.ZU;2-3
Fonte:
ISI
Lingua:
ENG
Soggetto:
GENE SERRATE ENCODES; WING IMAGINAL DISC; CELL FATE; NOTCH LIGAND; TRANSMEMBRANE PROTEIN; CHICK HOMOLOG; DROSOPHILA; DELTA; EMBRYOS; FRINGE;
Keywords:
X-Serrate-1; Notch ligand; primary neurogenesis; Xenopus embryo;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
62
Recensione:
Indirizzi per estratti:
Indirizzo: Kinoshita, T Kwansei Gakuin Univ, Fac Sci, 1-1-155 Uegahara, Nishinomiya, Hyogo 6628501, Japan Kwansei Gakuin Univ 1-1-155 Uegahara Nishinomiya HyogoJapan 6628501
Citazione:
T. Kiyota et al., "X-Serrate-1 is involved in primary neurogenesis in Xenopus laevis in a complementary manner with X-Delta-1", DEV GENES E, 211(8-9), 2001, pp. 367-376

Abstract

Notch, Delta and Serrate encode transmembrane proteins that function in cell fate specification in the Drosophila melanogaster embryo. Here we reportgene expression patterns and functional characterization of a Xenopus Serrate homolog, X-Serrate-1. The isolated cDNA encoded a transmembrane proteinwith a Delta/Serrate/LAG-2 domain, 16 epidermal growth factor-like repeatsand a cysteine-rich region. Expression of X-Serrate-1 was observed ubiquitously from unfertilized egg to tadpole, but an upregulation occurred in thetailbud stage embryo. Adult expression was found in eye, brain, kidney, heart, spleen and ovary. Whole-mount in situ hybridization revealed that the organ-related expression in eye, brain, heart and kidney occurred from an early stage of rudiment formation. Overexpression of X-Serrate-1 led to a reduction of primary neurons, whereas an intracellularly deleted form of X-Serrate-1 increased the number of primary neurons. Although the function of X-Serrate-1 in primary neurogenesis was quite similar to that of X-Delta-1, expression of X-Serrate-1 and X-Delta-1 did not affect each other. Co-injection experiments showed that wild-type X-Serrate-1 and X-Delta-1 suppressedoverproduction of primary neurons induced by dominant-negative forms of X-Delta-l and X-Serrate-1, respectively. These results suggest that X-Serrate-l regulates the patterning of primary neurons in a complementary manner with X-Delta-1-mediated Notch signaling.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 02/04/20 alle ore 20:02:07