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Titolo:
Differentiating primary pathophysiologic from secondary adaptational processes
Autore:
Levine, J; Chengappa, KNR; Gershon, S; Drevets, W;
Indirizzi:
Univ Pittsburgh, Sch Med, Western Psychiat Inst & Clin, Pittsburgh, PA USAUniv Pittsburgh Pittsburgh PA USA ychiat Inst & Clin, Pittsburgh, PA USA
Titolo Testata:
DEPRESSION AND ANXIETY
fascicolo: 2, volume: 14, anno: 2001,
pagine: 105 - 111
SICI:
1091-4269(2001)14:2<105:DPPFSA>2.0.ZU;2-Y
Fonte:
ISI
Lingua:
ENG
Soggetto:
SOLUBLE INTERLEUKIN-2 RECEPTORS; POSTTRAUMATIC-STRESS-DISORDER; OBSESSIVE-COMPULSIVE DISORDER; PANIC DISORDER; MAJOR DEPRESSION; SCHIZOPHRENIC-PATIENTS; ANTIDEPRESSANT DRUGS; BASOLATERAL AMYGDALA; FACIAL EXPRESSIONS; PREFRONTAL CORTEX;
Keywords:
adaptation; physiological; amygdala; receptors; interleukin 2; anxiety; depression;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Social & Behavioral Sciences
Clinical Medicine
Citazioni:
84
Recensione:
Indirizzi per estratti:
Indirizzo: Levine, J Beersheva Mental Hlth Ctr, POB 4600, Beer Sheva, Israel Beersheva Mental Hlth Ctr POB 4600 Beer Sheva Israel a, Israel
Citazione:
J. Levine et al., "Differentiating primary pathophysiologic from secondary adaptational processes", DEPRESS ANX, 14(2), 2001, pp. 105-111

Abstract

The following manuscript is mainly conceptual in nature. It should be readwith reservation. since the relevance of its suggestions have yet to be proven. Basically it proposes two rules for the differentiation between primary illness related pathophysiological vs. secondary adaptational processes. These rules may guide hypotheses generation for further research that is aimed at understanding psychiatric disorders and their shared and unshared mechanisms. For example, in the case of anxiety disorders and depression, itmay be of interest to learn if their shared properties are of primary pathophysiological or secondary adaptational significance. We first present some historical observations on the development of the concept of secondary adaptational processes. '' We assume such adaptational processes are generatedby the organism in order to compensate for primary pathophysiological malfunction or impairment. Next, we propose rules that may enable the dissection of secondary adaptational from primary pathophysiological processes. We also discuss the possible implications of designing studies to son out theseprocesses, suggesting that the understanding of adaptational processes, may explain the effects of ''placebo treatment. " Finally we illustrate the application of these rules by two examples: a) amygdala activation, a biological alteration shared by anxiety disorders and major depression and b) elevated plasma soluble interleukin 2 receptor, an unshared property by anxietydisorders and major depression. Also, the first example relates to a biological perturbation associated with a primary pathophysiological mechanism, while the second represents a biological alteration associated with secondary adaptational processes. (C) 2001 Wiley-Liss, Inc.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 19/01/20 alle ore 08:54:04