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Titolo:
Ethanol- and nicotine-induced membrane changes in embryonic and neonatal chick brains
Autore:
Miller, RR; Heckel, CD; Koss, WJ; Montague, SL; Greenman, AL;
Indirizzi:
Hillsdale Coll, Dept Biol, Hillsdale, MI 49242 USA Hillsdale Coll Hillsdale MI USA 49242 Dept Biol, Hillsdale, MI 49242 USA
Titolo Testata:
COMPARATIVE BIOCHEMISTRY AND PHYSIOLOGY C-TOXICOLOGY & PHARMACOLOGY
fascicolo: 2, volume: 130, anno: 2001,
pagine: 163 - 178
SICI:
1532-0456(200110)130:2<163:EANMCI>2.0.ZU;2-T
Fonte:
ISI
Lingua:
ENG
Soggetto:
FATTY-ACID COMPOSITION; NUTRITIONAL REGULATION; CHRONIC-ALCOHOLICS; MESSENGER-RNAS; MALIC ENZYME; SMOKING; EXPOSURE; PREGNANCY; SYNTHASE; LIVER;
Keywords:
ethanol; nicotine; membranes; fatty acids; embryo; neonatal; chick; brain; lipid peroxidation; acetylcholine esterase;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
57
Recensione:
Indirizzi per estratti:
Indirizzo: Miller, RR Hillsdale Coll, Dept Biol, 33 E Coll St, Hillsdale, MI 49242 USA Hillsdale Coll 33 E Coll St Hillsdale MI USA 49242 MI 49242 USA
Citazione:
R.R. Miller et al., "Ethanol- and nicotine-induced membrane changes in embryonic and neonatal chick brains", COMP BIOC C, 130(2), 2001, pp. 163-178

Abstract

In order to study the effects of EtOH and/or nicotine on brain membrane fatty acid composition, various concentrations of EtOH and/or nicotine were injected into the air sac of chicken eggs at 0 days of incubation. Controls were injected with saline. Experimental groups were injected with either 200 mu mol EtOH/kg egg, 100 mu mol nicotine/kg egg, 200 mu mol nicotine/kg egg, 200 mu mol EtOH/kg and 100 mu mol nicotine/kg egg, or 200 mu mol EtOH/kgand 200 mu mol nicotine/kg egg. In all experimental groups, EtOH- and nicotine-induced decreases in brain long-chain polyunsaturated membrane fatty acids were observed in stage 44 embryos, stage 45 embryos, and neonatal chicks. These EtOH- and nicotine-induced decreases in brain membrane polyunsaturated fatty acids correlated with elevated levels of brain lipid hydroperoxides and reduced brain acetyleholinesterase (AChE; EC. 3.1.1.7) activities. (C) 2001 Elsevier Science Inc. All rights reserved.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 23/01/20 alle ore 12:27:16