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Titolo:
Dehydroepiandrosterone (DHEA) stimulates glucose uptake in rat adipocytes:activation of phospholipase D
Autore:
Ishizawa, M; Ishizuka, T; Kajita, K; Miura, A; Kanoh, Y; Kimura, M; Yasuda, K;
Indirizzi:
Gifu Univ, Sch Med, Dept Gen Med, Dept Internal Med 3, Gifu 5008705, JapanGifu Univ Gifu Japan 5008705 d, Dept Internal Med 3, Gifu 5008705, Japan
Titolo Testata:
COMPARATIVE BIOCHEMISTRY AND PHYSIOLOGY B-BIOCHEMISTRY & MOLECULAR BIOLOGY
fascicolo: 3, volume: 130, anno: 2001,
pagine: 359 - 364
SICI:
1096-4959(200110)130:3<359:D(SGUI>2.0.ZU;2-7
Fonte:
ISI
Lingua:
ENG
Soggetto:
PROTEIN-KINASE-C; PHOSPHATIDYLINOSITOL 3-KINASE; INCREASES DIACYLGLYCEROL; INSULIN-RESISTANCE; BC3H-1 MYOCYTES; PHORBOL ESTERS; TRANSPORT; TRANSLOCATION; PHOSPHATIDYLCHOLINE; HYDROLYSIS;
Keywords:
dehydroepiandrosterone; adrenal androgen; phospholipase D; glucose uptake; rat adipocytes; diacylglycerol; [H-3]phosphatidylethanol; [methyl-H-3]choline;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
32
Recensione:
Indirizzi per estratti:
Indirizzo: Ishizuka, T Gifu Univ, Sch Med, Dept Gen Med, Dept Internal Med 3, Tsukasamachi 40, Gifu 5008705, Japan Gifu Univ Tsukasamachi 40 Gifu Japan 5008705u 5008705, Japan
Citazione:
M. Ishizawa et al., "Dehydroepiandrosterone (DHEA) stimulates glucose uptake in rat adipocytes:activation of phospholipase D", COMP BIOC B, 130(3), 2001, pp. 359-364

Abstract

We examined the effect of dehydroepiandrosterone (DHEA) on glucose uptake and phospholipase D (PLD) activation in rat adipocytes. DHEA (1 muM) provoked a twofold increase in [H-3]2-deoxyglucose (DG) uptake for 30 min. Incorporation of [H-3]-glycerol into diacylglycerol was increased 150% above basal level for 20 min after stimulation with 1 muM DHEA. DHEA increased PLD activity, measured by the incorporation into [H-3]phosphatidylethanol in [H-3]palmitate labelled rat adipocytes, or by [H-3]choline release in [methyl-H-3]choline labeled rat adipocytes. Our results suggest that DHEA stimulatesglucose uptake with activation of PLD in rat adipocytes. (C) 2001 ElsevierScience Inc. All rights reserved.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 04/04/20 alle ore 08:27:09