Catalogo Articoli (Spogli Riviste)

OPAC HELP

Titolo:
Morphological and functional retinal impairment in Alzheimer's disease patients
Autore:
Parisi, V; Restuccia, R; Fattapposta, F; Mina, C; Bucci, MG; Pierelli, F;
Indirizzi:
Univ Roma Tor Vergata, Clin Oculist, Rome, Italy Univ Roma Tor Vergata Rome Italy Tor Vergata, Clin Oculist, Rome, Italy Fdn Oftalmol GB Bietti, Rome, Italy Fdn Oftalmol GB Bietti Rome ItalyFdn Oftalmol GB Bietti, Rome, Italy Osped Fatebenefratelli Isola Tiberina, Div Oculist, AfaR IRCCS, Rome, Italy Osped Fatebenefratelli Isola Tiberina Rome Italy faR IRCCS, Rome, Italy Univ Roma La Sapienza, Ist Clin Malattie Nervose & Mentali, I-00185 Rome, Italy Univ Roma La Sapienza Rome Italy I-00185 & Mentali, I-00185 Rome, Italy Ist Neurol Mediterraneo NEUROMED, Pozzilli, Italy Ist Neurol Mediterraneo NEUROMED Pozzilli Italy UROMED, Pozzilli, Italy
Titolo Testata:
CLINICAL NEUROPHYSIOLOGY
fascicolo: 10, volume: 112, anno: 2001,
pagine: 1860 - 1867
SICI:
1388-2457(200110)112:10<1860:MAFRII>2.0.ZU;2-H
Fonte:
ISI
Lingua:
ENG
Soggetto:
OPTICAL COHERENCE TOMOGRAPHY; NERVE-FIBER LAYER; AMYLOID PRECURSOR PROTEIN; MULTIPLE-SCLEROSIS PATIENTS; PATTERN ELECTRORETINOGRAM; OCULAR HYPERTENSION; GANGLION-CELLS; ALTERNATING GRATINGS; NEURAL CONDUCTION; VISUAL PATHWAYS;
Keywords:
Alzheimer's disease; pattern electroretinogram; retinal ganglion cells; optical coherence tomography;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
57
Recensione:
Indirizzi per estratti:
Indirizzo: Parisi, V Univ Roma Tor Vergata, Clin Oculist, Rome, Italy Univ Roma Tor Vergata Rome Italy a, Clin Oculist, Rome, Italy
Citazione:
V. Parisi et al., "Morphological and functional retinal impairment in Alzheimer's disease patients", CLIN NEU, 112(10), 2001, pp. 1860-1867

Abstract

Objective: Our study aims to assess the optic nerve fiber layer thickness in vivo, the function of the innermost retinal layer and whether a correlation exists between morphological and functional parameters in patients affected by Alzheimer's Disease (AD). Methods: Seventeen AD patients (mean age 70.37 +/- 6.1 years, best corrected visual acuity >8/10 with refractive error between +/-3 sf, intra-ocular pressure (IOP) < 18 mmHg) were enrolled. They were compared to 14 age-matched controls. Nerve fiber layer (NFL) thickness was measured by optical coherence tomography (OCT). Three different measurements in each quadrant (superior, inferior, nasal, and temporal) were taken and averaged. The data in all quadrants (12 values averaged) were identified as NFL Overall. Retinal function was assessed by pattern electroretinogram (PERG) recordings using high-contrast (80%) checkerboard stimuli subtending 15 min of the visual areand reversed at the rate of two reversals/s. Results: In AD eyes, there was a significant (P < 0.01) reduction in NFL thickness in each quadrant and in the NFL Overall evaluation compared with the values observed in control eyes. PERGs showed a significant (P < 0.01) delay in N35, P50 and N95 implicit times, and reduction in N35-P50 and P50-N95 amplitudes. NFL Overall values were significantly correlated (P < 0.01) to the PERG P50 and N95 implicit times and P50-N95 amplitude. No correlations (P > 0.01) between NFL values and other PERG parameters (N35 implicit time, N35-P50 amplitude) were found. Conclusions: Our results suggest that in AD patients, there is a reductionof NFL thickness evaluated in vivo by OCT and this morphological abnormality is related to a retinal dysfunction as revealed by abnormal PERG responses. (C) 2001 Published by Elsevier Science Ireland Ltd.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 22/01/20 alle ore 07:20:58