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Titolo:
Variant effect of first- and second-generation antihistamines as clues to their mechanism of action on the sneeze reflex in the common cold
Autore:
Muether, PS; Gwaltney, JM;
Indirizzi:
Univ Virginia, Sch Med, Dept Internal Med, Div Epidemiol & Virol, Charlottesville, VA 22908 USA Univ Virginia Charlottesville VA USA 22908 Charlottesville, VA 22908 USA Aachen Med Sch, Aachen, Germany Aachen Med Sch Aachen GermanyAachen Med Sch, Aachen, Germany
Titolo Testata:
CLINICAL INFECTIOUS DISEASES
fascicolo: 9, volume: 33, anno: 2001,
pagine: 1483 - 1488
SICI:
1058-4838(20011101)33:9<1483:VEOFAS>2.0.ZU;2-V
Fonte:
ISI
Lingua:
ENG
Soggetto:
CLEMASTINE FUMARATE; NASAL SECRETIONS; RHINOVIRUS COLDS; HISTAMINE; CHALLENGES; INFECTION; TRIAL;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
31
Recensione:
Indirizzi per estratti:
Indirizzo: Gwaltney, JM Univ Virginia, Sch Med, Dept Internal Med, Div Epidemiol & Virol, Charlottesville, VA 22908 USA Univ Virginia Charlottesville VA USA 22908 lle, VA 22908 USA
Citazione:
P.S. Muether e J.M. Gwaltney, "Variant effect of first- and second-generation antihistamines as clues to their mechanism of action on the sneeze reflex in the common cold", CLIN INF D, 33(9), 2001, pp. 1483-1488

Abstract

Treatment with first-generation antihistamines reduces sneezing, rhinorrhea, nasal mucus weight, and, in some instances, cough in subjects with experimental or natural colds; however, treatment with second-generation antihistamines has not been effective for these complaints in trials in subjects with natural colds. This article reports the negative results of a clinical trial with loratadine, a second-generation antihistamine, in adults in the rhinovirus challenge model. This finding in the highly controlled setting of the challenge model confirms the earlier negative studies with second-generation antihistamines in natural colds. First-generation antihistamines block both histaminic and muscarinic receptors as well as passing the blood-brain barrier. Second-generation antihistamines mainly block histaminic receptors and do not pass the blood-brain barrier. The effectiveness of first-generation antihistamines in blocking sneezing in colds may be due primarilyto neuropharmacological manipulation of histaminic and muscarinic receptors in the medulla.

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Documento generato il 23/10/20 alle ore 11:22:10