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Titolo:
Magnetocardiographic mapping of QRS fragmentation in patients with a history of malignant tachyarrhythmias
Autore:
Godde, P; Agrawal, R; Muller, HP; Czerski, K; Endt, P; Steinhoff, U; Oeff, M; Schultheiss, HP; Behrens, S;
Indirizzi:
Free Univ Berlin, Klinikum Benjamin Franklin, Med Klin 2, Abt Kardiol & Pulmol,Dept Cardiol & Pulm Dis, D-12200 Berlin, Germany Free Univ Berlin Berlin Germany D-12200 ulm Dis, D-12200 Berlin, Germany Fed Inst Phys Technol, Berlin, Germany Fed Inst Phys Technol Berlin Germany Inst Phys Technol, Berlin, Germany
Titolo Testata:
CLINICAL CARDIOLOGY
fascicolo: 10, volume: 24, anno: 2001,
pagine: 682 - 688
SICI:
0160-9289(200110)24:10<682:MMOQFI>2.0.ZU;2-B
Fonte:
ISI
Lingua:
ENG
Soggetto:
SIGNAL-AVERAGED ELECTROCARDIOGRAM; SUSTAINED VENTRICULAR-TACHYCARDIA; PARKINSON-WHITE SYNDROME; CORONARY-ARTERY DISEASE; MYOCARDIAL-INFARCTION; SINUS RHYTHM; LATE POTENTIALS; HEART-DISEASE; INTEGRAL MAPS; BODY-SURFACE;
Keywords:
magnetocardiography; mapping; ventricular arrhythmias; coronary artery disease; arrhythmogenic substrate;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Citazioni:
43
Recensione:
Indirizzi per estratti:
Indirizzo: Behrens, S Free Univ Berlin, Klinikum Benjamin Franklin, Med Klin 2, Abt Kardiol & Pulmol,Dept Cardiol & Pulm Dis, Hindenburgdamm 30, D-12200 Berlin,Germany Free Univ Berlin Hindenburgdamm 30 Berlin Germany D-12200 many
Citazione:
P. Godde et al., "Magnetocardiographic mapping of QRS fragmentation in patients with a history of malignant tachyarrhythmias", CLIN CARD, 24(10), 2001, pp. 682-688

Abstract

Background: The identification of patients at increased risk for ventricular tachycardia or ventricular fibrillation (VT/VF) and sudden cardiac deathhas consequences for therapeutic options and thus may reduce mortality in patients with coronary artery disease (CAD). Hypothesis: We hypothesized that the intra-QRS fragmentation in magnetocardiographic recordings is increased in patients with CAD and with a history of VT/VF. Methods: Multichannel magnetocardiography (MCG) was carried out in 34 healthy controls, 42 patients with CAD without a history of VT/VF, and 43 patients with CAD and with a history of VT/VF. The intra-QRS fragmentation was quantified by anew fragmentation score. Its spatial distribution was investigated using two-dimensional (2-D) contour maps according to the sensor position of the 49-channel magnetogradiometer. Results: Patients with CAD and with a history of VT/VF had significantly increased QRS fragmentation compared with patients with CAD without VT/VF orcontrols (72.9 +/- 37.5, 48.5 +/- 14.3, and 42.5 +/-7.8, respectively; p<0.05). The area of high fragmentation in 2-D contour maps was twice as largein patients with than in those without a history of VT/VF (represented by the number of MCG channels with high fragmentation: 26.3<plus/minus>15.5 vs. 12.4 +/-9.9, p<0.0001). Patients prone to VT/VF could be identified with a sensitivity of 64% and a specificity of 90%. Conclusion: In patients with CAD and with a history of VT/VF, intra-QRS fragmentation is increased and the area of high fragmentation in 2-D contour maps is enlarged. These findings may be helpful in identifying patients with CAD at risk for malignant tachyarrhythmias.

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Documento generato il 04/07/20 alle ore 14:47:39