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Titolo:
Optimization of the chiral separation of some 2-arylpropionic acids on an avidin column by modeling a combined response
Autore:
Smet, E; Staelens, L; Vander Heyden, Y; Baeyens, WRG; Aboul-Enein, HY; Van der Weken, G; Garcia-Campana, AM;
Indirizzi:
State Univ Ghent, Fac Pharmaceut Sci, Lab Drug Qual Control, B-9000 Ghent,Belgium State Univ Ghent Ghent Belgium B-9000 Qual Control, B-9000 Ghent,Belgium Free Univ Brussels, Inst Pharmaceut, ChemoAC, Brussels, Belgium Free Univ Brussels Brussels Belgium rmaceut, ChemoAC, Brussels, Belgium King Faisal Specialist Hosp & Res Ctr MBC03, Dept Biol & Med Res, Pharmaceut Anal Lab, Riyadh 11211, Saudi Arabia King Faisal Specialist Hosp & Res Ctr MBC03 Riyadh Saudi Arabia 11211 ia Univ Granada, Fac Sci, Dept Analyt Chem, Granada, Spain Univ Granada Granada Spain a, Fac Sci, Dept Analyt Chem, Granada, Spain
Titolo Testata:
CHIRALITY
fascicolo: 9, volume: 13, anno: 2001,
pagine: 556 - 567
SICI:
0899-0042(200110)13:9<556:OOTCSO>2.0.ZU;2-G
Fonte:
ISI
Lingua:
ENG
Soggetto:
PERFORMANCE LIQUID-CHROMATOGRAPHY; ALPHA-1-ACID GLYCOPROTEIN COLUMN; DERRINGER DESIRABILITY FUNCTION; CAPILLARY ZONE ELECTROPHORESIS; CONJUGATED COLUMN; ENANTIOMERIC SEPARATION; EXPERIMENTAL-DESIGN; STATIONARY-PHASE; HUMAN PLASMA; ANTIINFLAMMATORY DRUGS;
Keywords:
Derringer's desirability function; multicriteria decision making approach; protein chiral stationary phase; method optimization; chiral separation;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
53
Recensione:
Indirizzi per estratti:
Indirizzo: Baeyens, WRG State Univ Ghent, Fac Pharmaceut Sci, Lab Drug Qual Control, Harelbekestr 72, B-9000 Ghent, Belgium State Univ Ghent Harelbekestr 72 Ghent Belgium B-9000 elgium
Citazione:
E. Smet et al., "Optimization of the chiral separation of some 2-arylpropionic acids on an avidin column by modeling a combined response", CHIRALITY, 13(9), 2001, pp. 556-567

Abstract

The enantiomeric separation of some nonsteroidal antiinflammatory drugs was investigated on an avidin column. An experimental design approach (central composite design) was used to evaluate the effects of three method parameters (pH, concentration of organic modifier, and buffer concentration) on the analysis time and the resolution, as well as to model these responses. This revealed that the organic modifier concentration and sometimes the pH are significant parameters to control because of their influence on both analysis time and resolution. Furthermore, the central composite design results were combined in a multicriteria decision-making approach in order to obtain a set of optimal experimental conditions leading to the most desirable compromise between resolution and analysis time. Chirality 13:556-567, 2001. (C) 2001 Willey-Liss, Inc.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 31/03/20 alle ore 09:08:49