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Titolo:
CYTOLOGIC DIAGNOSIS OF PANCREATIC CYSTIC LESIONS - A PROSPECTIVE-STUDY OF 28 PERCUTANEOUS ASPIRATES
Autore:
CENTENO BA; WARSHAW AL; MAYOSMITH W; SOUTHERN JF; LEWANDROWSKI K;
Indirizzi:
MASSACHUSETTS GEN HOSP,DEPT PATHOL,SURG SERV,CLIN LABS,GRAY 5,FRUIT ST BOSTON MA 02114 MASSACHUSETTS GEN HOSP,DEPT PATHOL,SURG SERV,CLIN LABS BOSTON MA 02114 MASSACHUSETTS GEN HOSP,DEPT SURG BOSTON MA 02114 MASSACHUSETTS GEN HOSP,DEPT RADIOL BOSTON MA 02114 HARVARD UNIV,SCH MED,DEPT SURG BOSTON MA 02115 HARVARD UNIV,SCH MED,DEPT PATHOL BOSTON MA 02115
Titolo Testata:
Acta cytologica
fascicolo: 4, volume: 41, anno: 1997,
pagine: 972 - 980
SICI:
0001-5547(1997)41:4<972:CDOPCL>2.0.ZU;2-O
Fonte:
ISI
Lingua:
ENG
Soggetto:
FINE-NEEDLE ASPIRATION; ISLET-CELL TUMORS; DIFFERENTIAL-DIAGNOSIS; MUCINOUS CYSTADENOCARCINOMA; FLUID ANALYSIS; NEOPLASMS; CYSTADENOMA; PSEUDOCYSTS;
Keywords:
PANCREATIC DISEASES; CYSTS; ASPIRATION BIOPSY;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
19
Recensione:
Indirizzi per estratti:
Citazione:
B.A. Centeno et al., "CYTOLOGIC DIAGNOSIS OF PANCREATIC CYSTIC LESIONS - A PROSPECTIVE-STUDY OF 28 PERCUTANEOUS ASPIRATES", Acta cytologica, 41(4), 1997, pp. 972-980

Abstract

PURPOSE: To prospectively evaluate fine needle aspiration biopsy (FNAB) of pancreatic cystic lesions. STUDY DESIGN: We performed a blind, prospective study on percutaneous aspirates from 28 radiographically identified cysts, including 6 inflammatory cysts (5 pseudocysts and 1 abscess), 4 serous cystadenomas, 1 cystic islet cell tumor, 5 mucinous cystic neoplasms, 6 mucinous cystadenocarcinomas and 6 nonpancreatic cysts. RESULTS: Four of six (67%) cystadenocarcinomas were identified asmalignant, and the other two, which lacked sufficient morphologic criteria for malignancy, as consistent with mucinous cystic neoplasm. Twoof five mucinous cystic neoplasms were correctly classified. One, which contained atypical cells, did not appear to be mucinous on the ThinPrep, and one, which lacked an epithelial component, was suggested because of the presence of mucin in the background, The fifth one contained inflammatory cells only. One of four serous cystadenomas produced adiagnostic specimen. FNAB of the cystic islet cell tumor was nondiagnostic. Five of six inflammatory cysts (83%) were correctly diagnosed, whereas one case produced an acellular, nondiagnostic specimen. Six of28 (23%) cases were nonpancreatic cysts, aspirated under the presumption that they were pancreatic cysts based on radiologic studies: only one case, a papillary cystadenocarcinoma of the stomach, was correctlydiagnosed; the other five cases were nondiagnostic, and in two of these the assumption that the cysts were pancreatic in origin precluded an accurate classification. CONCLUSION: FNAB of pancreatic cystic lesions can differentiate mucinous from nonmucinous pancreatic cysts and provide definitive evidence of malignancy. In some cases, serous cystadenomas can be diagnosed. Pseudocysts can be suspected on the basis of an inflammatory smear lacking both epithelial cells and background mucin, but this finding is not specific. Nonpancreatic lesions constitute a significant percentage of cases aspirated as pancreatic cysts and present a major pitfall in cytologic interpretation.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 29/11/20 alle ore 17:14:03