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Titolo:
The effects of streptokinase and hydroxyethyl starch on in vitro clot disruption by ultrasound
Autore:
Adler, Y; Attar, D; Vaturi, M; Golovchiner, G; Iakobishvili, Z; Battler, A; Siegel, RJ; Birnbaum, Y;
Indirizzi:
Rabin Med Ctr, Dept Cardiol, IL-49100 Petah Tiqwa, Israel Rabin Med Ctr Petah Tiqwa Israel IL-49100 , IL-49100 Petah Tiqwa, Israel Felsenstein Res Inst, Lab Cardiovasc Biol, Petah Tiqwa, Israel FelsensteinRes Inst Petah Tiqwa Israel ovasc Biol, Petah Tiqwa, Israel Cedars Sinai Med Ctr, Div Cardiol, Los Angeles, CA 90048 USA Cedars Sinai Med Ctr Los Angeles CA USA 90048 , Los Angeles, CA 90048 USA
Titolo Testata:
CARDIOVASCULAR DRUGS AND THERAPY
fascicolo: 2, volume: 15, anno: 2001,
pagine: 119 - 123
SICI:
0920-3206(200103)15:2<119:TEOSAH>2.0.ZU;2-1
Fonte:
ISI
Lingua:
ENG
Soggetto:
LOW-FREQUENCY ULTRASOUND; TISSUE-PLASMINOGEN ACTIVATOR; ACUTE MYOCARDIAL-INFARCTION; THROMBOLYSIS IN-VITRO; BLOOD-COAGULATION; TRANSCUTANEOUS ULTRASOUND; EXTERNAL ULTRASOUND; ARTERIAL THROMBI; FACTOR-VIII; ALBUMIN;
Keywords:
clot disruption; hydroxyethyl starch; streptokinase; thrombolysis; ultrasound;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
53
Recensione:
Indirizzi per estratti:
Indirizzo: Birnbaum, Y Rabin Med Ctr, Dept Cardiol, Beilinson Campus, IL-49100 Petah Tiqwa, Israel Rabin Med Ctr Beilinson Campus Petah Tiqwa Israel IL-49100 el
Citazione:
Y. Adler et al., "The effects of streptokinase and hydroxyethyl starch on in vitro clot disruption by ultrasound", CARDIO DRUG, 15(2), 2001, pp. 119-123

Abstract

Background: In vitro studies showed that low-frequency ultrasound (US) causes blood clot dissolution. This effect is augmented with thrombolytics, microbubbles and microparticles. However, in animal models of transcutaneous delivery, US alone is not effective, probably due to attenuation of US energy by overlying skin. When combined with thrombolytics or microbubbles, transcutaneous US is highly effective. Purpose: To assess the synergistic effect of low-intensity low-frequency US and saline, hydroxyethyl starch (RAES)(a non-gas filled microparticle containing solution), streptokinase (STK),and their combination on blood clot disruption. Methods: Human blood clotsfrom 4 healthy donors, 2-4 hours old, were immersed for 0, 15, or 30 min in 37 degreesC in 10 ml of the above-mentioned solutions, and then were randomized to 10 see of 20 kHz US or no US. The % difference in weight was calculated. Results: Immersion for 30 min without US resulted in 13.8 +/- 1.2% clot lysis in saline, and 22.0 +/- 1.3%, 21.7 +/- 2.1%, and 23.2 +/- 1.9% in STK, HAES, and STK + HAES, respectively (p = 0.002). US augmented clot lysis in all groups and at all time points. With low-intensity US, HAES was not better than saline. Howe er, the combination of HAES + STK with US resulted in larger clot disruption at 15 see incubation time (46.7 +/- 3.2%) than with saline (29.6 +/- 2.1%), HAES (29.6 +/- 2.5%), and STK (32.8 +/- 3.6%) (p < 0.001). Conclusion: low-frequency, low-intensity US combined with HAES and STK resulted in greater clot disruption at short incubation times. This combination may assist in achieving faster reperfusion in in vivo models.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 07/08/20 alle ore 07:12:39