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Titolo:
Polymorphisms in glutathione S-transferases (GSTM1 and GSTT1) and survivalafter treatment for breast cancer
Autore:
Ambrosone, CB; Sweeney, C; Coles, BF; Thompson, PA; McClure, GY; Korourian, S; Fares, MY; Stone, A; Kadlubar, FF; Hutchins, LF;
Indirizzi:
Mt Sinai Sch Med, Derald H Ruttenberg Canc Ctr, New York, NY 10029 USA Mt Sinai Sch Med New York NY USA 10029 g Canc Ctr, New York, NY 10029 USA Univ Minnesota, Div Epidemiol, Minneapolis, MN 55454 USA Univ Minnesota Minneapolis MN USA 55454 demiol, Minneapolis, MN 55454 USA Natl Ctr Toxicol Res, Div Mol Epidemiol, Jefferson, AR 72079 USA Natl Ctr Toxicol Res Jefferson AR USA 72079 miol, Jefferson, AR 72079 USA Univ Arkansas Med Sci, Arkansas Canc Res Ctr, Little Rock, AR 72205 USA Univ Arkansas Med Sci Little Rock AR USA 72205 Little Rock, AR 72205 USA Univ Texas, MD Anderson Canc Ctr, Dept Epidemiol, Houston, TX 77030 USA Univ Texas Houston TX USA 77030 tr, Dept Epidemiol, Houston, TX 77030 USA
Titolo Testata:
CANCER RESEARCH
fascicolo: 19, volume: 61, anno: 2001,
pagine: 7130 - 7135
SICI:
0008-5472(20011001)61:19<7130:PIGS(A>2.0.ZU;2-Z
Fonte:
ISI
Lingua:
ENG
Soggetto:
GENETIC POLYMORPHISMS; OVARIAN-CANCER; TUMOR-MARKER; CYCLOPHOSPHAMIDE; ANTIOXIDANT; ASSOCIATION; ADRIAMYCIN; ENZYMES; M1; P1;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
41
Recensione:
Indirizzi per estratti:
Indirizzo: Ambrosone, CB Mt Sinai Sch Med, Derald H Ruttenberg Canc Ctr, Box 1130,1 Gustave L Levy Pl, New York, NY 10029 USA Mt Sinai Sch Med Box 1130,1 Gustave L Levy Pl New York NY USA 10029
Citazione:
C.B. Ambrosone et al., "Polymorphisms in glutathione S-transferases (GSTM1 and GSTT1) and survivalafter treatment for breast cancer", CANCER RES, 61(19), 2001, pp. 7130-7135

Abstract

The response to treatment for breast cancer is likely predicted by a number of disease and tumor tissue characteristics, many of which are under active investigation. One area that has received little attention is that of endogenous capabilities to respond to reactive oxygen species and subsequent byproducts resulting from radiation therapy and a number of chemotherapeutic agents, preventing cytotoxicity toward tumor cells. The glutathione S-transferases are key conjugating enzymes in this response, and GSTM1 and GSTT1have deletion polymorphisms that result in no enzyme activity. In this retrospective study, we evaluated the role of GSTM1- and GSTT1-null genotypes on disease-free and overall survival among 251 women who received treatmentfor incident, primary breast cancer. Women were identified through Tumor Registry records and normal archived tissue retrieved for genotyping. Adjusting for age, race, and stage at diagnosis, women with null genotypes for GSTM1 and GSTT1 had reduced hazard of death [adjusted hazard ratio (HR), 0.59; 95% confidence interval (CI), 0.36-0.97; and HR, 0.51; CI, 0.29-0.90, respectively] in relation to those with alleles present. Furthermore, women who were null for both GSTM1 and GSTT1 had one-third the hazard of death of those with alleles for both genes present (adjusted HR, 0.28; 95% CI, 0.11-0.70). Similar relationships were noted for risk of recurrence. These data indicate that interindividual differences in activity of enzymes that prevent therapy-generated reactive oxidant damage may have an important impact ondisease recurrence and overall survival.

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Documento generato il 21/01/21 alle ore 02:25:36