Catalogo Articoli (Spogli Riviste)

OPAC HELP

Titolo:
Therapeutic efficacy of E2F1 in pancreatic cancer correlates with TP73 induction
Autore:
Rodicker, F; Stiewe, T; Zimmermann, S; Putzer, BM;
Indirizzi:
Univ Essen Gesamthsch, Sch Med, Inst Mol Biol, Ctr Canc Res & Canc Therapy, D-45122 Essen, Germany Univ Essen Gesamthsch Essen Germany D-45122 rapy, D-45122 Essen, Germany
Titolo Testata:
CANCER RESEARCH
fascicolo: 19, volume: 61, anno: 2001,
pagine: 7052 - 7055
SICI:
0008-5472(20011001)61:19<7052:TEOEIP>2.0.ZU;2-6
Fonte:
ISI
Lingua:
ENG
Soggetto:
2',2'-DIFLUORODEOXYCYTIDINE; EXPRESSION; SAFETY; P53;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
12
Recensione:
Indirizzi per estratti:
Indirizzo: Putzer, BM Univ Essen Gesamthsch, Sch Med, Inst Mol Biol, Ctr Canc Res & Canc Therapy, Hufelandstr 55, D-45122 Essen, Germany Univ Essen Gesamthsch Hufelandstr 55 Essen Germany D-45122 any
Citazione:
F. Rodicker et al., "Therapeutic efficacy of E2F1 in pancreatic cancer correlates with TP73 induction", CANCER RES, 61(19), 2001, pp. 7052-7055

Abstract

Pancreatic cancer is particularly resistant to apoptosis by antineoplasticagents, which is partly attributable to the lack of functional p53. Here we show that E2F1 in combination with the most clinically efficient drug, gemcitabine, resulted in a strong induction of apoptosis independent of functional p53, whereas the effect of either therapy atone varied between different cell lines. Intratumoral injection of a helper-dependent adenovirus vector expressing E2F1 plus drug treatment resulted in a significant reductionof tumor volume. The therapeutic effect is directly correlated with the induction of the p53 homologue p73, suggesting that the recently discovered E2F1/p73 pathway plays a critical role in cancer therapy.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 02/07/20 alle ore 21:21:57