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Titolo:
Sphingolipids as biomarkers of fumonisin exposure and risk of esophageal squamous cell carcinoma in China
Autore:
Abnet, CC; Borkowf, CB; Qiao, YL; Albert, PS; Wang, E; Merrill, AH; Mark, SD; Dong, ZW; Taylor, PR; Dawsey, SM;
Indirizzi:
NCI, Ctr Canc Res, Canc Prevent Studies Branch, Bethesda, MD 20892 USA NCI Bethesda MD USA 20892 Prevent Studies Branch, Bethesda, MD 20892 USA Chinese Acad Med Sci, Inst Canc, Beijing, Peoples R China Chinese Acad MedSci Beijing Peoples R China , Beijing, Peoples R China NCI, Div Canc Treatment & Diag, Bethesda, MD USA NCI Bethesda MD USANCI, Div Canc Treatment & Diag, Bethesda, MD USA Emory Univ, Rollins Res Ctr, Dept Biochem, Atlanta, GA 30322 USA Emory Univ Atlanta GA USA 30322 Ctr, Dept Biochem, Atlanta, GA 30322 USA NCI, Div Canc Epidemiol & Genet, Bethesda, MD USA NCI Bethesda MD USANCI, Div Canc Epidemiol & Genet, Bethesda, MD USA
Titolo Testata:
CANCER CAUSES & CONTROL
fascicolo: 9, volume: 12, anno: 2001,
pagine: 821 - 828
SICI:
0957-5243(200111)12:9<821:SABOFE>2.0.ZU;2-3
Fonte:
ISI
Lingua:
ENG
Soggetto:
NUTRITION INTERVENTION TRIALS; DISEASE-SPECIFIC MORTALITY; REPUBLIC-OF-CHINA; FUSARIUM-MONILIFORME; CANCER INCIDENCE; SPHINGOSINE; MYCOTOXINS; LINXIAN; SPHINGANINE; CORN;
Keywords:
esophageal cancer; fumonisin; sphinganine; sphingolipids; sphingosine;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Citazioni:
38
Recensione:
Indirizzi per estratti:
Indirizzo: Abnet, CC NCI, Ctr Canc Res, Canc Prevent Studies Branch, 6006 Execut Blvd,Room 321,Bethesda, MD 20892 USA NCI 6006 Execut Blvd,Room 321 Bethesda MD USA 20892 MD 20892 USA
Citazione:
C.C. Abnet et al., "Sphingolipids as biomarkers of fumonisin exposure and risk of esophageal squamous cell carcinoma in China", CANC CAUSE, 12(9), 2001, pp. 821-828

Abstract

Objective: Ecologic studies of esophageal squamous cell carcinoma (ESCC) have reported an association with consumption of maize contaminated with Fusarium verticillioides, which produce fungal toxins referred to as fumonisins. Fumonisins disrupt sphingolipid metabolism and serum sphingolipids have been proposed as biomarkers of fumonisin exposure. We conducted a prospective nested case-control study to examine the relationship between serum sphingolipids and ESCC incidence. Methods: Cases and controls were selected from a large prospective trial conducted in Linxian, People's Republic of China. Ninety-eight ESCC cases were randomly selected from the 639 incident ESCC ascertained during the initial 5.25 years of follow-up; 185 controls were also randomly selected basedon the distribution of cases among six age and sex strata. Concentrations of sphinganine and sphingosine were determined by high-performance liquid chromatography in serum collected at the study baseline. Results: No significant associations were found between serum sphingosine,sphinganine, or the sphinganine/sphingosine ratio and ESCC incidence in conditional and unconditional logistic regression models with adjustment for age, sex, tobacco use, and alcohol use. Conclusion: Our study is the first prospective study to assess the relationship between sphingolipid levels, as biomarkers of fumonisin exposure, andcancer incidence. We found no significant association between sphingolipidlevels and risk of ESCC.

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Documento generato il 30/09/20 alle ore 02:57:53