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Titolo:
Positron emission tomography (PET) for staging low-grade non-Hodgkin's lymphomas (NHL)
Autore:
Najjar, F; Hustinx, R; Jerusalem, G; Fillet, G; Rigo, P;
Indirizzi:
Univ Hosp, Div Nucl Med, Liege, Belgium Univ Hosp Liege BelgiumUniv Hosp, Div Nucl Med, Liege, Belgium Univ Hosp, Div OncoHematol, Liege, Belgium Univ Hosp Liege BelgiumUniv Hosp, Div OncoHematol, Liege, Belgium
Titolo Testata:
CANCER BIOTHERAPY AND RADIOPHARMACEUTICALS
fascicolo: 4, volume: 16, anno: 2001,
pagine: 297 - 304
SICI:
1084-9785(200108)16:4<297:PET(FS>2.0.ZU;2-7
Fonte:
ISI
Lingua:
ENG
Soggetto:
FDG-PET; F-18 FLUORODEOXYGLUCOSE; MALIGNANT-LYMPHOMA; ATTENUATION CORRECTION; COMPUTED-TOMOGRAPHY; DISEASE; ONCOLOGY; CT;
Keywords:
FDG-PET; fluorine-18 fluorodeoxyglucose; non-Hodgkin's lymphoma; positron emission tomography;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
23
Recensione:
Indirizzi per estratti:
Indirizzo: Hustinx, R CHU Sart Tilman, B 35, B-4000 Liege 1, Belgium CHU Sart Tilman B 35 Liege Belgium 1 , B-4000 Liege 1, Belgium
Citazione:
F. Najjar et al., "Positron emission tomography (PET) for staging low-grade non-Hodgkin's lymphomas (NHL)", CANC BIO R, 16(4), 2001, pp. 297-304

Abstract

Although positron emission tomography (PET) imaging is now recognized as auseful tool for staging intermediate and high-grade non-Hodgkin's lymphoma(NHL), few data are available regarding its accuracy in low grade NHL. We therefore studied 36 patients with histologically proven low-grade NHL. Whole-body 2-(fluorine-18) fluoro-2-deoxy-D-glucose (FDG) PET was performed atthe time of initial diagnosis (n = 21) or for disease recurrence (n = 15) prior to any treatment. PET results were compared to those of physical examination and computed tomography (CT). PET studies were read without knowledge of any clinical data. Any focus of increased activity was described and given a probability of malignancy using a 5 point-scale (0: normal to 4: definitively malignant). An individual biopsy was available for a total of 31 lesions. The sensitivity and specificity were 87% and 100% for FDG-PET, 100% and 100% for physical examination and 90% and 100% for CT respectively. In addition, 42 of 97 peripheral lymph node lesions observed by FDG-PET were clinically undetected, whereas the physical examination detected 23 additional nodal lesions. PET and CT both indicated 12 extranodal lymphomatous localizations. FDG-PET showed 7 additional extranodal lesions while 5 additional unconfirmed lesions were observed on CT Regarding bone marrow infiltration, PET and biopsy were concordant in 24 patients with 11 trite positive (TP) and 13 trite negative (TY). However PET was FN in I I patients and no biopsy was performed in one patient. The combination PET/CT/physical examination seems to be moresensitive than the conventional approach for staging low grade NHL. Its sensitivity however is unacceptably low for diagnosing bone marrow infiltration.

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Documento generato il 26/01/20 alle ore 00:50:33