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Titolo:
FDG-PET in adrenocortical carcinoma
Autore:
Becherer, A; Vierhapper, H; Potzi, C; Karanikas, G; Kurtaran, A; Schmaljohann, J; Staudenherz, A; Dudczak, R; Kletter, K;
Indirizzi:
Univ Vienna, Klin Nukl Med, Dept Nucl Med, A-1090 Vienna, Austria Univ Vienna Vienna Austria A-1090 Dept Nucl Med, A-1090 Vienna, Austria Univ Vienna, Dept Endocrinol & Metab, Vienna, Austria Univ Vienna ViennaAustria na, Dept Endocrinol & Metab, Vienna, Austria Univ Vienna, Ludwig Boltzmann Inst Nucl Med, Vienna, Austria Univ Vienna Vienna Austria wig Boltzmann Inst Nucl Med, Vienna, Austria
Titolo Testata:
CANCER BIOTHERAPY AND RADIOPHARMACEUTICALS
fascicolo: 4, volume: 16, anno: 2001,
pagine: 289 - 295
SICI:
1084-9785(200108)16:4<289:FIAC>2.0.ZU;2-B
Fonte:
ISI
Lingua:
ENG
Soggetto:
ADRENAL-CORTICAL CARCINOMA; ONCOLOGICAL APPLICATIONS; PROGNOSTIC FACTORS; CLINICAL-FEATURES; DOXORUBICIN; EXPERIENCE; RESECTION; CISPLATIN; SURAMIN; PATIENT;
Keywords:
adrenocortical carcinoma; positron emission tomography; fluorodeoxyglucose;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
24
Recensione:
Indirizzi per estratti:
Indirizzo: Becherer, A Univ Vienna, Klin Nukl Med, Dept Nucl Med, Wahringer Gurtel 18-20, A-1090 Vienna, Austria Univ Vienna Wahringer Gurtel 18-20 Vienna Austria A-1090 tria
Citazione:
A. Becherer et al., "FDG-PET in adrenocortical carcinoma", CANC BIO R, 16(4), 2001, pp. 289-295

Abstract

Adrenal cortical carcinoma (ACC) is a rare malignant neoplasm with a poor prognosis. Radical surgery of the primary tumor and of local as well as of distant recurrence is the only effective treatment, and requires accurate and early localization of recurrent tumors. In this regard, we prospectivelyscanned 10 patients with ACC, 8 during follow-up and 2 at primary work-up. In all patients PET scans from the fleck to the upper thighs were obtained45 minutes after injection of 370 MBq [F-18]FDG. Reading was done visually, with the investigator blinded to the results of other diagnostic Modalities. All known sites of ACC lesions showed markedly increased FDG uptake. In3 patients, previously unknown lesions were identified by PET in the lung (One lesion), the abdomen (3 lesions), and the skeleton (multiple), respectively. One false positive liver focus was shown by PET aside from the true positive lung metastases in the same patient. The sensitivity/specificity of PET based oil different organs Was 100/97%, that based on the number of PET-detected lesions (N = 23) was 100/95%. PET altered or influenced the tumor stage in 3/10 patients, modifying the subsequent therapeutic management in 2/10 patients. We conclude that FDG-PET is highly useful in ACC and should be included in the work-up for initial staging as well as for follow-up.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 29/01/20 alle ore 18:58:29