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Titolo:
Treatment outcome of maxillary sinus squamous cell carcinoma
Autore:
Hayashi, T; Nonaka, S; Bandoh, N; Kobayashi, Y; Imada, M; Harabuchi, Y;
Indirizzi:
Asahikawa Med Coll, Dept Otolaryngol, Asahikawa, Hokkaido 0788510, Japan Asahikawa Med Coll Asahikawa Hokkaido Japan 0788510 kkaido 0788510, Japan
Titolo Testata:
CANCER
fascicolo: 6, volume: 92, anno: 2001,
pagine: 1495 - 1503
SICI:
0008-543X(20010915)92:6<1495:TOOMSS>2.0.ZU;2-I
Fonte:
ISI
Lingua:
ENG
Soggetto:
MULTIDISCIPLINARY TREATMENT; RADIOTHERAPY; CHEMOTHERAPY; MANAGEMENT; NECK;
Keywords:
maxillary sinus carcinoma; multimodality therapy; combined therapy; prognostic factors; treatment result;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
22
Recensione:
Indirizzi per estratti:
Indirizzo: Hayashi, T Asahikawa Med Coll, Dept Otolaryngol, Midorigaoka Higashi 2-1-1-1, Asahikawa, Hokkaido 0788510, Japan Asahikawa Med Coll Midorigaoka Higashi 2-1-1-1 Asahikawa Hokkaido Japan 0788510
Citazione:
T. Hayashi et al., "Treatment outcome of maxillary sinus squamous cell carcinoma", CANCER, 92(6), 2001, pp. 1495-1503

Abstract

BACKGROUND. Optimal treatment policies of maxillary sinus carcinoma remainto be defined. METHODS. Seventy-four patients with squamous cell carcinoma of maxillary sinus were treated at Department of Otolaryngology, Asahikawa Medical College between 1983 and 1997, The T classification according to the 1997 International Union Against Cancer was as follows: 9 with T2, 35 with T3, and 30 with T4. Eight patients had lymph node metastasis with NI at diagnosis. Of 62 patients who started multimodality therapy that comprised preoperative radiochemotherapy including local irradiation with total dose of 50 grays along with concomitant intramaxillary arterial infusion of 5-fluorouracil withtotal dose of 5000 mg followed by total or partial maxillectomy, 59 received the complete therapy. Eleven patients had to be treated with radiotherapy alone, and 1 patient received postoperative radiotherapy. The median follow-up time for surviving patients was 117 months. RESULTS. The 5-year overall survival, disease free survival, and local control (LC) rates for all patients were 58.5%, 63.7%, and 73.6%, respectively. The patients who underwent multimodality therapy showed significantly better 5-year overall survival, disease free survival, and LC rates as compared with those who underwent radiotherapy alone (68.5% vs. 9.1%; 73.2% vs. 18.2%; 84.0% vs. 18.2%; P < 0.0001 each). Multivariate analysis revealed thatT classification and treatment modality are independent predictors for disease free survival. CONCLUSIONS. The authors' treatment method, which did not include any complicated techniques, produced higher survival and LC rates because of high effectiveness of multimodality therapy. They concluded that their multimodality therapy could offer a better chance for cure from maxillary sinus carcinoma at many institutions. (C) 2001 American Cancer Society.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 05/12/20 alle ore 20:04:06