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Titolo:
The pharmacology and toxicology of "ecstasy" (MDMA) and related drugs
Autore:
Kalant, H;
Indirizzi:
Univ Toronto, Dept Pharmacol, Toronto, ON M5S 1A8, Canada Univ Toronto Toronto ON Canada M5S 1A8 macol, Toronto, ON M5S 1A8, Canada Addict Res Fdn Div, Ctr Addict & Mental Hlth, Toronto, ON, Canada Addict Res Fdn Div Toronto ON Canada & Mental Hlth, Toronto, ON, Canada
Titolo Testata:
CANADIAN MEDICAL ASSOCIATION JOURNAL
fascicolo: 7, volume: 165, anno: 2001,
pagine: 917 - 928
SICI:
0820-3946(20011002)165:7<917:TPATO">2.0.ZU;2-A
Fonte:
ISI
Lingua:
ENG
Soggetto:
(ECSTASY)-INDUCED SEROTONIN NEUROTOXICITY; AUXILIARY LIVER-TRANSPLANTATION; IMPAIRED COGNITIVE PERFORMANCE; NEUROLEPTIC MALIGNANT SYNDROME; AMPHETAMINE DESIGNER DRUGS; FULMINANT HEPATIC-FAILURE; 3,4-METHYLENEDIOXYMETHAMPHETAMINE MDMA; METHYLENEDIOXYMETHAMPHETAMINE MDMA; DISCRIMINATIVE STIMULUS; INDUCED HYPERTHERMIA;
Tipo documento:
Review
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
191
Recensione:
Indirizzi per estratti:
Indirizzo: Kalant, H Univ Toronto, Dept Pharmacol, Med Sci Bldg, Toronto, ON M5S 1A8,Canada Univ Toronto Med Sci Bldg Toronto ON Canada M5S 1A8 1A8, Canada
Citazione:
H. Kalant, "The pharmacology and toxicology of "ecstasy" (MDMA) and related drugs", CAN MED A J, 165(7), 2001, pp. 917-928

Abstract

"ECSTASY" (MDMA) AND RELATED DRUGS ARE AMPHETAMINE DERIVATIVES that also have some of the pharmacological properties of mescaline. They have become popular with participants in "raves," because they enhance energy, endurance, sociability and sexual arousal. This vogue among teenagers and young adults, together with the widespread belief that "ecstasy" is a safe drug, has led to a thriving illicit traffic in it. But these drugs also have serious toxic effects, both acute and chronic, that resemble those previously seen with other amphetamines and are caused by an excess of the same sympathomimetic actions for which the drugs are valued by the users. Neurotoxicity to the serotonergic system in the brain can also cause permanent physical and psychiatric problems. A detailed review of the literature has revealed over87 "ecstasy"-related fatalities, caused by hyperpyrexia, rhabdomyolysis, intravascular coagulopathy, hepatic necrosis, cardiac arrhythmias, cerebrovascular accidents, and drug-related accidents or suicide. The toxic or even fatal dose range overlaps the range of recreational dosage. The available evidence does not yet permit an accurate assessment of the size of the problem presented by the use of these drugs.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 28/01/20 alle ore 21:30:30