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Titolo:
Anandamide induces cardiovascular and respiratory reflexes via vasosensorynerves in the anaesthetized rat
Autore:
Smith, PJW; McQueen, DS;
Indirizzi:
Univ Edinburgh, Sch Med, Dept Neurosci, Edinburgh EH8 9JZ, Midlothian, Scotland Univ Edinburgh Edinburgh Midlothian Scotland EH8 9JZ Midlothian, Scotland
Titolo Testata:
BRITISH JOURNAL OF PHARMACOLOGY
fascicolo: 3, volume: 134, anno: 2001,
pagine: 655 - 663
SICI:
0007-1188(200110)134:3<655:AICARR>2.0.ZU;2-G
Fonte:
ISI
Lingua:
ENG
Soggetto:
SENSORY NERVES; CANNABINOID RECEPTORS; VANILLOID RECEPTORS; ANESTHETIZED RATS; CAPSAICIN; PAIN; BIOSYNTHESIS; MECHANISMS; RELAXATION; INJECTION;
Keywords:
anandamide; capsaicin; sensory nerves; cardiovascular-respiratory reflexes; vanilloid receptor;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
42
Recensione:
Indirizzi per estratti:
Indirizzo: Smith, PJW Univ Edinburgh, Sch Med, Dept Neurosci, 1 George Sq, Edinburgh EH8 9JZ, Midlothian, Scotland Univ Edinburgh 1 George Sq Edinburgh Midlothian Scotland EH8 9JZ
Citazione:
P.J.W. Smith e D.S. McQueen, "Anandamide induces cardiovascular and respiratory reflexes via vasosensorynerves in the anaesthetized rat", BR J PHARM, 134(3), 2001, pp. 655-663

Abstract

1 We tested the hypothesis that sensory nerves innervating blood vessels play a role in the local and systemic regulation of the cardiovascular and respiratory (CVR) systems. We measured CVR reflexes evoked by administrationof anandamide (86 - 863 nmoles) and capsaicin (0.3 - 10 nmoles) into the hindlimb vasculature of anaesthetized rats.2 Anandamide and capsaicin each caused a rapid dose-dependent reflex fall in blood pressure and an increase in ventilation when injected intra-arterially into the hindlimb.3 Action of both agonists at the vanilloid receptor (VR1) on perivascular sensory nerves was investigated using capsazepine (1 mg kg(-1) i.a.) a competitive VR1 antagonist, ruthenium red (1 mg kg(-1) i.a.), a non-competitiveantagonist at VR1, or a desensitizing dose of capsaicin (200 nmoles i.a.). The cannabinoid receptor antagonist SR141716 (1 mg kg(-1) i.a.) was used to determine agonist activity at the CB, receptor.4 Capsazepine, ruthenium red, or acute VR1 desensitization by capsaicin-pretreatment, markedly attenuated the reflex CVR responses evoked by anandamide and capsaicin (P <0.05; paired Student's t-test). Blockade of CB, had nosignificant effect on the responses to anandamide.5 Local sectioning of the femoral and sciatic nerves attenuated CVR responses to anandamide and capsaicin (P <0.05). Vagotomy or carotid sinus sectioning had no significant effect on anandamide-or capsaicin-induced responses.6 These data demonstrate that both the endogenous cannabinoid, anandamide,and the vanilloid, capsaicin, evoke CVR reflexes when injected intra-arterially into the rat hindlimb. These responses appear to be mediated reflexlyvia VR1 located on sensory nerve endings within the hindlimb vasculature.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 02/04/20 alle ore 19:04:01