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Titolo:
Determination of effects of antiepileptic drugs on SNAREs-mediated hippocampal monoamine release using in vivo microdialysis
Autore:
Murakami, T; Okada, M; Kawata, Y; Zhu, G; Kamata, A; Kaneko, S;
Indirizzi:
Hirosaki Univ, Sch Med, Dept Neuropsychiat, Hirosaki, Aomori 0368216, Japan Hirosaki Univ Hirosaki Aomori Japan 0368216 rosaki, Aomori 0368216, Japan
Titolo Testata:
BRITISH JOURNAL OF PHARMACOLOGY
fascicolo: 3, volume: 134, anno: 2001,
pagine: 507 - 520
SICI:
0007-1188(200110)134:3<507:DOEOAD>2.0.ZU;2-O
Fonte:
ISI
Lingua:
ENG
Soggetto:
PERFORMANCE LIQUID-CHROMATOGRAPHY; ADENOSINE RECEPTOR SUBTYPES; DOPAMINE RELEASE; CALCIUM-CHANNEL; ION CHANNELS; SYNAPTIC TRANSMISSION; SEROTONERGIC SYSTEM; STRIATAL DOPAMINE; RAT HIPPOCAMPUS; CEREBRAL-CORTEX;
Keywords:
carbamezepine; valproate; zonisamide; botulinum toxin; serotonin; dopamine; exocytosis;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
55
Recensione:
Indirizzi per estratti:
Indirizzo: Okada, M Hirosaki Univ, Sch Med, Dept Neuropsychiat, Hirosaki, Aomori 0368216, Japan Hirosaki Univ Hirosaki Aomori Japan 0368216 omori 0368216, Japan
Citazione:
T. Murakami et al., "Determination of effects of antiepileptic drugs on SNAREs-mediated hippocampal monoamine release using in vivo microdialysis", BR J PHARM, 134(3), 2001, pp. 507-520

Abstract

I To elucidate possible mechanisms underlying the effects of carbamazepine(CBZ), valproate (VPA) and zonisamide (ZNS) on neurotransmitter exocytosis, the interaction between these three antiepileptic drugs (AEDs) and botulinum toxins (BoNTs) on basal, Ca2+- and K+-evoked release of dopamine (DA) and serotonin (5-HT) were determined by microdialysis in the hippocampus of freely moving rats.2 Basal release of monoamine was decreased by pre-microinjection of the syntaxin inhibitor, BoNT/C, but only weakly affected by the synaptobrevin inhibitor, BoNT/B. Ca2+-evoked release was inhibited by BoNT/C selectively. K+-evoked release was reduced by BoNT/B predominantly and BoNT/C weakly,3 Perfusion with low and high concentrations of CBZ and ZNS increased and decreased basal monoamine release, respectively. Perfusion with VPA increased basal 5-HT release concentration-dependently, whereas basal DA release was affected by VPA biphasic concentration-dependently, similar to CBZ and ZNS. This stimulatory action of AEDs on basal release was inhibited by BoNT/C predominantly.4 Ca2+-evoked monoamine release was increased by low concentrations of CBZ, ZNS and VPA, but decreased by high concentrations. These effects of the AEDs on Ca2+-evoked release were inhibited by BoNT/C, but not by BoNT/B.5 K+-evoked monoamine release was reduced by AEDs concentration-dependently. The inhibitory effect of these three AEDs on K+-evoked release was inhibited by BoNT/B, but not by BoNT/C,6 These findings suggest that the therapeutic-relevant concentration of CBZ, VPA and ZNS affects exocytosis of DA and 5-HT, the enhancement of syntaxin-mediated monoamine release during resting stage, and the inhibition of synaptobrevin-mediated release during depolarizing stage.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 25/01/20 alle ore 15:43:33