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Titolo:
Applications of the Morris water maze in the study of learning and memory
Autore:
DHooge, R; De Deyn, PP;
Indirizzi:
Univ Antwerp, Born Bunge Fdn, Lab Neurochem & Behav, B-2610 Wilrijk, Belgium Univ Antwerp Wilrijk Belgium B-2610 hem & Behav, B-2610 Wilrijk, Belgium Univ Antwerp, Middelheim Hosp, Memory Clin, Dept Neurol, B-2610 Wilrijk, Belgium Univ Antwerp Wilrijk Belgium B-2610 Dept Neurol, B-2610 Wilrijk, Belgium
Titolo Testata:
BRAIN RESEARCH REVIEWS
fascicolo: 1, volume: 36, anno: 2001,
pagine: 60 - 90
SICI:
0165-0173(200108)36:1<60:AOTMWM>2.0.ZU;2-L
Fonte:
ISI
Lingua:
ENG
Soggetto:
LONG-TERM POTENTIATION; AMYLOID PRECURSOR PROTEIN; NUCLEUS BASALIS MAGNOCELLULARIS; NMDA RECEPTOR ANTAGONIST; CONTROLLED CORTICAL IMPACT; IMPROVES SPATIAL MEMORY; E-DEFICIENT MICE; PROLYL ENDOPEPTIDASE INHIBITOR; MUCOPOLYSACCHARIDOSIS TYPE-VII; FOREBRAIN CHOLINERGIC SYSTEM;
Keywords:
Morris water maze; spatial learning and memory; spatial navigation; behavioral testing; rats and mice;
Tipo documento:
Review
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
380
Recensione:
Indirizzi per estratti:
Indirizzo: D'Hooge, R Univ Antwerp, Born Bunge Fdn, Lab Neurochem & Behav, Univ Pl 1,B-2610 Wilrijk, Belgium Univ Antwerp Univ Pl 1 Wilrijk Belgium B-2610 Wilrijk, Belgium
Citazione:
R. D'Hooge e P.P. De Deyn, "Applications of the Morris water maze in the study of learning and memory", BRAIN RES R, 36(1), 2001, pp. 60-90

Abstract

The Morris water maze (MWM) was described 20 years ago as a device to investigate spatial learning and memory in laboratory rats. In the meanwhile, it has become one of the most frequently used laboratory tools in behavioralneuroscience. Many methodological variations of the MWM task have been andare being used by research groups in many different applications. However,researchers have become increasingly aware that MWM performance is influenced by factors such as apparatus or training procedure as well as by the characteristics of the experimental animals (sex, species/strain, age, nutritional state, exposure to stress or infection). Lesions in distinct brain regions like hippocampus, striatum, basal forebrain, cerebellum and cerebral cortex were shown to impair MWM performance, but disconnecting rather than destroying brain regions relevant for spatial learning may impair MWM performance as well. Spatial learning in general and MWM performance in particular appear to depend upon the coordinated action of different brain regions and neurotransmitter systems constituting a functionally integrated neural network. Finally, the MWM task has often been used in the validation of rodent models for neurocognitive disorders and the evaluation of possible neurocognitive treatments. Through its many applications, MWM testing gained a position at the very core of contemporary neuroscience research. (C) 2001 Elsevier Science B V All rights reserved.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 19/01/20 alle ore 00:34:17