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Titolo:
Simultaneous activation and opioid modulation of long-term potentiation inthe dentate gyrus and the hippocampal CA3 region after stimulation of the perforant pathway in freely moving rats
Autore:
Krug, M; Brodemann, R; Wagner, M;
Indirizzi:
Otto Von Guericke Univ, Fac Med, Inst Pharmacol & Toxicol, D-39120 Magdeburg, Germany Otto Von Guericke Univ Magdeburg Germany D-39120 9120 Magdeburg, Germany
Titolo Testata:
BRAIN RESEARCH
fascicolo: 1, volume: 913, anno: 2001,
pagine: 68 - 77
SICI:
0006-8993(20010914)913:1<68:SAAOMO>2.0.ZU;2-5
Fonte:
ISI
Lingua:
ENG
Soggetto:
LOW-FREQUENCY STIMULATION; TIME-DEPENDENT REVERSAL; SYNAPTIC RESPONSES; HZ STIMULATION; LOCALIZATION; LTP; RECEPTORS; SYNAPSES; IMMUNOREACTIVITY; ORGANIZATION;
Keywords:
binaltorphimine; CA3; dentate gyrus; evoked field potential; freely moving rat; funaltrexamine; long-term potentiation; naloxone; naltrindole; paired-pulse plasticity; perforant pathway;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
33
Recensione:
Indirizzi per estratti:
Indirizzo: Brodemann, R Otto Von Guericke Univ, Fac Med, Inst Pharmacol & Toxicol, Leipziger Str 44, D-39120 Magdeburg, Germany Otto Von Guericke Univ LeipzigerStr 44 Magdeburg Germany D-39120
Citazione:
M. Krug et al., "Simultaneous activation and opioid modulation of long-term potentiation inthe dentate gyrus and the hippocampal CA3 region after stimulation of the perforant pathway in freely moving rats", BRAIN RES, 913(1), 2001, pp. 68-77

Abstract

Recent investigations indicate monosynaptic activation by the perforant pathway (pp) of the dentate gyrus and the CA3 region. While short-term potentiation and long-term potentiation (LTP) and its opioid modulation are frequently described for the dentate gyrus, data for the CA3 region are rare. Therefore, evoked potentials and opioid modulation of UP were directly compared in both target regions of the pp. Male Wistar rats were chronically implanted with a bipolar stimulation electrode in the pp (angular bundle) and two recording electrodes in the dorsal dentate gyrus and the CA3 region. Stimulation of the pp in the freely behaving animals induced short-latency evoked potentials in both target structures which were compared with respect to waveform, latency, amplitude and signs of short- and long-term neuronal plasticity. The short-latency potential in the CA3 region seemed to be a monosynaptic potential which displayed LTP sensitive to the N-methyl-D-aspartate receptor antagonist, MK 801, and depotentiating stimulation. After application of specific opioid antagonists at the mu-, delta- and kappa -opioid receptor subtypes, naloxone, funaltrexamine, naltrindole and binaltorphimine, different effects on induction and maintenance of LTP of the population spike were found both within the dentate gyrus and between the dentate gyrus and the CA3 region. The results show marked diminution of LTP in the dentate gyrus only for naloxone and naltrindole and only small, if any, effectsof naloxone, on UP in the CA3 region. Thus, neuronal plasticity in the direct perforant pathway input to the CA3 region seems not to be under such substantial opioidergic control. LTP would be inducible in that region even when UP in the input formation, the dentate gyrus, and transsynaptic LTP viathe mossy fibres are blocked. (C) 2001 Elsevier Science B.V. All rights reserved.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 09/04/20 alle ore 13:25:35