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Titolo:
Propofol and sodium thiopental protect against MK-801-induced neuronal necrosis in the posterior cingulate/retrosplenial cortex
Autore:
Jevtovic-Todorovic, V; Wozniak, DF; Powell, S; Olney, JW;
Indirizzi:
Washington Univ, Sch Med, Dept Anesthesiol, St Louis, MO 63110 USA Washington Univ St Louis MO USA 63110 Anesthesiol, St Louis, MO 63110 USA Washington Univ, Sch Med, Dept Psychiat, St Louis, MO 63110 USA WashingtonUniv St Louis MO USA 63110 pt Psychiat, St Louis, MO 63110 USA
Titolo Testata:
BRAIN RESEARCH
fascicolo: 2, volume: 913, anno: 2001,
pagine: 185 - 189
SICI:
0006-8993(20010921)913:2<185:PASTPA>2.0.ZU;2-9
Fonte:
ISI
Lingua:
ENG
Soggetto:
NMDA ANTAGONIST; NEUROTOXICITY; PHENCYCLIDINE; MK-801; BRAIN;
Keywords:
adult rat; GABAergic agent; NMDA antagonist; neuroprotection; neurotoxicity;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
20
Recensione:
Indirizzi per estratti:
Indirizzo: Jevtovic-Todorovic, V Univ Virginia, Hlth Syst, Dept Anesthesiol, Box 800710, Charlottesville, VA 22908 USA Univ Virginia Box 800710 Charlottesville VA USA 22908
Citazione:
V. Jevtovic-Todorovic et al., "Propofol and sodium thiopental protect against MK-801-induced neuronal necrosis in the posterior cingulate/retrosplenial cortex", BRAIN RES, 913(2), 2001, pp. 185-189

Abstract

N-Methyl-D-aspartate (NMDA) antagonists act by an anti-excitotoxic action to provide neuroprotection against acute brain injury, but these agents canalso cause toxic effects. In low doses they induce reversible neuronal injury, but in higher doses they cause irreversible degeneration of cerebrocortical neurons. GABAmimetic drugs protect against the reversible neurotoxic changes in rat brain. Here we show that two GABAmimetic anesthetic agents -propofol and sodium thiopental - protect against the irreversible neurodegenerative reaction induced by the powerful NMDA antagonist, MK-801. (C) 2001 Elsevier Science B.V. All rights reserved.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 20/01/20 alle ore 10:36:48