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Titolo:
Inhibition of Na+/H+ exchange by SM-20220 attenuates free fatty acid efflux in rat cerebral cortex during ischemia-reperfusion injury
Autore:
Pilitsis, JG; Diaz, FG; ORegan, MH; Phillis, JW;
Indirizzi:
Wayne State Univ, Sch Med, Dept Physiol, Detroit, MI 48201 USA Wayne StateUniv Detroit MI USA 48201 Dept Physiol, Detroit, MI 48201 USA Wayne State Univ, Dept Neurosurg, Detroit, MI 48201 USA Wayne State Univ Detroit MI USA 48201 pt Neurosurg, Detroit, MI 48201 USA Univ Detroit Mercy, Sch Dent, Detroit, MI 48219 USA Univ Detroit Mercy Detroit MI USA 48219 , Sch Dent, Detroit, MI 48219 USA
Titolo Testata:
BRAIN RESEARCH
fascicolo: 2, volume: 913, anno: 2001,
pagine: 156 - 158
SICI:
0006-8993(20010921)913:2<156:IONEBS>2.0.ZU;2-T
Fonte:
ISI
Lingua:
ENG
Soggetto:
EXTRACELLULAR ACIDOSIS; HIPPOCAMPAL-NEURONS; PH; 5-(N-ETHYL-N-ISOPROPYL)-AMILORIDE; PATHOPHYSIOLOGY; PHYSIOLOGY; RECOVERY; TISSUE; BRAIN;
Keywords:
cerebral ischemia; cerebroprotection; free fatty acid; phospholipase; Na+/H+ exchange; SM-20220;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
20
Recensione:
Indirizzi per estratti:
Indirizzo: Phillis, JW Wayne State Univ, Sch Med, Dept Physiol, 540 E Canfield, Detroit, MI 48201USA Wayne State Univ 540 E Canfield Detroit MI USA 48201 48201USA
Citazione:
J.G. Pilitsis et al., "Inhibition of Na+/H+ exchange by SM-20220 attenuates free fatty acid efflux in rat cerebral cortex during ischemia-reperfusion injury", BRAIN RES, 913(2), 2001, pp. 156-158

Abstract

The Na+/H+ exchanger (NHE) is activated during ischemia-reperfusion in an effort to restore intracellular pH to normal levels. Inhibition of NHE withnon-selective amiloride derivatives has been shown to be neuroprotective and to attenuate free fatty acid efflux during ischemia-reperfusion. We evaluated the effects of SM-20220 (20 muM), a highly selective and specific NHEinhibitor, applied topically onto rat cerebral cortex prior to and during a 20-min period of ischemia. SM-20220 application significantly reduced theischemia-evoked efflux of myristic, palmitic, and arachidonic acids duringboth ischemia and reperfusion with significant decreases in linoleic and docosahexaenoic levels during reperfusion. This study confirms the importance of NHEs in eliciting free fatty acid efflux, inhibition of which may be an essential component of the neuroprotective benefits of NHE inhibitors in ischemia-reperfusion injury. (C) 2001 Elsevier Science B.V. All rights reserved.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 26/01/20 alle ore 16:07:57