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Titolo:
Evidence for involvement of the neural pathway containing the peripheral vagus nerve, medullary visceral zone and central amygdaloid nucleus in neuroimmunomodulation
Autore:
Ge, X; Yang, ZJ; Duan, L; Rao, ZR;
Indirizzi:
Fourth Mil Med Univ, Inst Neurosci, Xian 710032, Peoples R China Fourth Mil Med Univ Xian Peoples R China 710032 710032, Peoples R China
Titolo Testata:
BRAIN RESEARCH
fascicolo: 1-2, volume: 914, anno: 2001,
pagine: 149 - 158
SICI:
0006-8993(20010928)914:1-2<149:EFIOTN>2.0.ZU;2-Q
Fonte:
ISI
Lingua:
ENG
Soggetto:
STIMULATION-INDUCED EXPRESSION; TO-BRAIN COMMUNICATION; CATECHOLAMINERGIC NEURONS; SICKNESS BEHAVIOR; FOS EXPRESSION; NOXIOUS-STIMULATION; SOLITARY TRACT; RAT; PROJECTION; CYTOKINES;
Keywords:
medullary visceral zone; central amygdaloid nucleus; subdiaphragmatic vagotomy; lipopolysaccharide neuroimmuno-modulation; rat;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
39
Recensione:
Indirizzi per estratti:
Indirizzo: Rao, ZR Fourth Mil Med Univ, Inst Neurosci, Xian 710032, Peoples R China Fourth Mil Med Univ Xian Peoples R China 710032 Peoples R China
Citazione:
X. Ge et al., "Evidence for involvement of the neural pathway containing the peripheral vagus nerve, medullary visceral zone and central amygdaloid nucleus in neuroimmunomodulation", BRAIN RES, 914(1-2), 2001, pp. 149-158

Abstract

It is now evident that a bidirectional communication network exists between the central nervous system (CNS) and immune system (IS). However, the wayin which the IS passes inform to the brain is not quite clear. In the present study, one of the neural pathways involved in the cytokine-to-brain communication was investigated in the rat. This pathway starts at the vagal nerve projecting to the medullary visceral zone (MVZ), an arc-shape band fromthe dorsomedial to ventrolateral area in the middle-caudal segment of the medulla oblongata, and terminates at the central amygdaloid nucleus (Cc) which receives projections from large catecholaminergic neurons in the MVZ. Animals were randomly divided into two experimental groups. Triple-labeling was used in Group I animals to combine wheat germ aggulutinin-conjugated horseradish peroxidase (WGA-HRP) retrograde tracing with anti-Fos and anti-tyrosine hydroxylase (TH) immunostaining. WGA-RP was stereotaxically injectedinto the unilateral Cc of the animals and, after a survival period of 48 h, intraperitoneal (IP) injection of lipopolysaccharide (LPS) was performed. Seven kinds of labeled neurons were observed in the MVZ, namely, HRP-, Fos- or TH-singly-labeled neurons; Fos/HRP-, Fos/TH- or HRP/TH-doubly-labeled neurons; and Fos/HRP/TH-triply-labeled neurons. As for Group II animals, bilateral subdiaphragmatic vagotomy (SDV) or sham operation was performed, followed 4 weeks later by IP injection of LPS. The number of Fos-positive neurons within the Cc and MVZ was significantly lower (P <0.01) in rats havingSDV when compared with those receiving sham operation. Our results suggestthat part of the peripheral immune information can be conveyed through thevagus to the catecholaminergic neurons in the MVZ, where it is transportedto the Cc. The MVZ is a neural relay station in the immune-to-brain communication and might play a significant role in neuroimmuno-modulation via thevagus-MVZ-Ce pathway. (C) 2001 Published by Elsevier Science B.V.

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Documento generato il 31/03/20 alle ore 04:42:53