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Titolo:
Temporal and spatial distribution of Fos protein in the lumbar spinal dorsal horn neurons in the rat with chronic constriction injury to the sciatic nerve
Autore:
Yamazaki, Y; Maeda, T; Someya, G; Wakisaka, S;
Indirizzi:
Niigata Univ, Grad Sch Med & Dent Sci, Div Oral Anat, Dept Oral Biol Sci, Niigata 9518514, Japan Niigata Univ Niigata Japan 9518514 Oral Biol Sci, Niigata 9518514, Japan Niigata Univ, Grad Sch Med & Dent Sci, Dept Tissue Regenerat & Reconstruct, Div Dent Anesthesiol, Niigata 9518514, Japan Niigata Univ Niigata Japan9518514 t Anesthesiol, Niigata 9518514, Japan Osaka Univ, Grad Sch Dent, Dept Oral Anat & Dev Biol, Suita, Osaka 5650871, Japan Osaka Univ Suita Osaka Japan 5650871 ev Biol, Suita, Osaka 5650871, Japan
Titolo Testata:
BRAIN RESEARCH
fascicolo: 1-2, volume: 914, anno: 2001,
pagine: 106 - 114
SICI:
0006-8993(20010928)914:1-2<106:TASDOF>2.0.ZU;2-J
Fonte:
ISI
Lingua:
ENG
Soggetto:
EXPERIMENTAL PERIPHERAL NEUROPATHY; NMDA ANTAGONIST TREATMENT; PRIMARY AFFERENT NEURONS; PRIMARY SENSORY NEURONS; PAIN-RELATED BEHAVIORS; C-FOS; SPONTANEOUS DISCHARGE; NEUROPEPTIDE-Y; CORD NEURONS; EXPRESSION;
Keywords:
Fos; spinal dorsal horn; chronic constriction injury;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
34
Recensione:
Indirizzi per estratti:
Indirizzo: Yamazaki, Y Niigata Univ, Grad Sch Med & Dent Sci, Div Oral Anat, Dept Oral Biol Sci, 2-5274 Gakkocho Dori, Niigata 9518514, Japan Niigata Univ 2-5274 Gakkocho Dori Niigata Japan 9518514 Japan
Citazione:
Y. Yamazaki et al., "Temporal and spatial distribution of Fos protein in the lumbar spinal dorsal horn neurons in the rat with chronic constriction injury to the sciatic nerve", BRAIN RES, 914(1-2), 2001, pp. 106-114

Abstract

The temporal and spatial expression pattern of Fos protein in spinal dorsal horn neurons was examined by immunohistochemistry in rats with chronic constriction injury (M) to the sciatic nerve. In normal animals, a few Fos-immunoreactive (-IR) neurons were detected in the dorsal horn of the lumbar spinal cord, Following induction of M, a very large number of Fos-IR neuronsappeared in the spinal dorsal horn, but a significant number of Fos-IR neurons were also observed in the contralateral dorsal horn where primary afferents of the injured sciatic nerve rarely project. Sham-operated animals also had a significant number of Fos-IR neurons in the dorsal horn bilaterally. The number of Fos-IR neurons reached its maximal level I day following placement of the ligatures (PO ld). The ratio of the number of Fos-IR neurons in the ipsilateral dorsal horn to the contralateral dorsal horn, however,had its peak level 3 days following CCI (3.1-fold increase compared to thecontralateral dorsal horn). The number of Fos-IR neurons in the dorsal horn gradually decreased, but increased again around PO 15d. On PO 30d, the number of Fos-IR neurons decreased and became comparable to that in normal animals. The present results indicate that the induction of Fos-IR neurons inthe dorsal horn caused by CCI is biphasic and reaches its maximal level onPO 3d, near the time of hyperalgesia onset. (C) 2001 Elsevier Science BY. All rights reserved.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 26/01/20 alle ore 09:44:16