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Titolo:
Decorin inhibits macrophage colony-stimulating factor proliferation of macrophages and enhances cell survival through induction of p27(Kip1) and p21(Waf1)
Autore:
Xaus, J; Comalada, M; Cardo, M; Valledor, AF; Celada, A;
Indirizzi:
Univ Barcelona, Fac Biol, Dept Fisiol, E-08028 Barcelona, Spain Univ Barcelona Barcelona Spain E-08028 Fisiol, E-08028 Barcelona, Spain Univ Barcelona, Fundacio August Pi Sunyer, E-08028 Barcelona, Spain Univ Barcelona Barcelona Spain E-08028 Sunyer, E-08028 Barcelona, Spain
Titolo Testata:
BLOOD
fascicolo: 7, volume: 98, anno: 2001,
pagine: 2124 - 2133
SICI:
0006-4971(20011001)98:7<2124:DIMCFP>2.0.ZU;2-F
Fonte:
ISI
Lingua:
ENG
Soggetto:
DERMATAN SULFATE PROTEOGLYCAN; GROWTH-FACTOR-BETA; GENE-EXPRESSION; EXTRACELLULAR-MATRIX; CYCLE PROGRESSION; HUMAN MONOCYTES; IN-VIVO; DS-PGII; APOPTOSIS; COLLAGEN;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
58
Recensione:
Indirizzi per estratti:
Indirizzo: Celada, A Univ Barcelona, Fac Biol, Dept Fisiol, Av Diagonal 645, E-08028 Barcelona,Spain Univ Barcelona Av Diagonal 645 Barcelona Spain E-08028 na,Spain
Citazione:
J. Xaus et al., "Decorin inhibits macrophage colony-stimulating factor proliferation of macrophages and enhances cell survival through induction of p27(Kip1) and p21(Waf1)", BLOOD, 98(7), 2001, pp. 2124-2133

Abstract

Decorin is a small proteoglycan that is ubiquitous in the extracellular matrix of mammalian tissues. It has been extensively demonstrated that decorin Inhibits tumor cell growth; however, no data have been reported on the effects of decorin In normal cells. Using nontransformed macrophages from bone marrow, results of this study showed that decorin Inhibits macrophage colony-stimulating factor (M-CSF)-dependent, proliferation by Inducing blockage at the G(1) phase of the cell cycle without affecting cell viability. in addition, decorin rescues macrophages from the Induction of apoptosis aftergrowth factor withdrawal. Decorin induces the expression of the cdk inhibitors p21(Waf1) and p27(Kip1). Using macrophages from mice where these geneshave been disrupted, inhibition of proliferation mediated by decorin is related to p27(Kip1) expression, whereas p21(Kip1) expression is necessary toprotect macrophages from apoptosis. Decorin also Inhibits M-CSF-dependent expression of MKP-1 and extends the kinetics of ERK activity, which Is characteristic when macrophages become activated instead of proliferating. The effect of decorin on macrophages is not due to its Interaction with epidermal growth factor or Interferon-gamma receptors. Furthermore, decorin increases macrophage adhesion to the extracellular matrix, and this may be partially responsible for the expression of P27(Kip1) and the modification of ERKactivity, but not for the increased cell survival. (C) 2001 by The American Society of Hematology.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 12/07/20 alle ore 06:45:37