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Titolo:
Homologous recombination as a mechanism of carcinogenesis
Autore:
Bishop, AJR; Schiestl, RH;
Indirizzi:
Harvard Univ, Sch Publ Hlth, Dept Canc Cell Biol, Boston, MA 02115 USA Harvard Univ Boston MA USA 02115 ept Canc Cell Biol, Boston, MA 02115 USA
Titolo Testata:
BIOCHIMICA ET BIOPHYSICA ACTA-REVIEWS ON CANCER
fascicolo: 3, volume: 1471, anno: 2001,
pagine: M109 - M121
SICI:
0304-419X(20010321)1471:3<M109:HRAAMO>2.0.ZU;2-S
Fonte:
ISI
Lingua:
ENG
Soggetto:
INDUCE INTRACHROMOSOMAL RECOMBINATION; DOUBLE-STRAND BREAK; DNA-DAMAGE RESPONSE; EYED UNSTABLE MUTATION; LI-FRAUMENI-SYNDROME; ATM-DEPENDENT PHOSPHORYLATION; TUMOR-SUPPRESSOR GENES; CELL-CYCLE CHECKPOINTS; ALU-ALU RECOMBINATION; BASE EXCISION-REPAIR;
Keywords:
cancer; homologous recombination; loss of heterozygosity; genomic instability disease; carcinogen-induced deletion;
Tipo documento:
Review
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
165
Recensione:
Indirizzi per estratti:
Indirizzo: Schiestl, RH Harvard Univ, Sch Publ Hlth, Dept Canc Cell Biol, 665 Huntington Ave, Boston, MA 02115 USA Harvard Univ 665 Huntington Ave Boston MA USA02115 02115 USA
Citazione:
A.J.R. Bishop e R.H. Schiestl, "Homologous recombination as a mechanism of carcinogenesis", BBA-REV CAN, 1471(3), 2001, pp. M109-M121

Abstract

Cancer develops when cells no longer follow their normal pattern of controlled growth. In the absence or disregard of such regulation, resulting fromchanges in their genetic makeup, these errant cells acquire a growth advantage, expanding into precancerous clones. Over the last decade many studieshave revealed the relevance of genomic mutation in this process, be it by misreplication, environmental damage or a deficiency in repairing endogenous and exogenous damage. Here we discuss homologous recombination as anothermechanism that can result in loss of heterozygosity or genetic rearrangements. Some of these genetic alterations may play a primary role in carcinogenesis, but they are more likely to be involved in secondary and subsequent steps of carcinogenesis by which recessive oncogenic mutations are revealed. Patients whose cells display an increased frequency of recombination alsohave an elevated frequency of cancer, further supporting the link between recombination and carcinogenesis. In addition, homologous recombination is induced by a wide variety of carcinogens, many of which are classically considered to be efficiently repaired by other repair pathways. Overall, homologous recombination is a process that has been widely overlooked but may bemore central to the process of carcinogenesis than previously described. (C) 2001 Elsevier Science B.V. All rights reserved.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 19/09/20 alle ore 18:16:53