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Titolo:
Ryanodine receptor channel-dependent glutathione transport in the sarcoplasmic reticulum of skeletal muscle
Autore:
Csala, M; Fulceri, R; Mandl, J; Benedetti, A; Banhegyi, G;
Indirizzi:
Univ Siena, Dipartimento Fisiopatol Med Sperimentale, I-53100 Siena, ItalyUniv Siena Siena Italy I-53100 ol Med Sperimentale, I-53100 Siena, Italy Semmelweis Univ Med, Dept Med Chem Pathobiochem & Mol Biol, H-1444 Budapest, Hungary Semmelweis Univ Med Budapest Hungary H-1444 ol, H-1444 Budapest, Hungary
Titolo Testata:
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
fascicolo: 3, volume: 287, anno: 2001,
pagine: 696 - 700
SICI:
0006-291X(20010928)287:3<696:RRCGTI>2.0.ZU;2-K
Fonte:
ISI
Lingua:
ENG
Soggetto:
LIVER MICROSOMAL VESICLES; CA2+ RELEASE CHANNELS; DISULFIDE-BOND FORMATION; ENDOPLASMIC-RETICULUM; REDOX SENSOR; COMPLEX;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
23
Recensione:
Indirizzi per estratti:
Indirizzo: Benedetti, A Univ Siena, Dipartimento Fisiopatol Med Sperimentale, Viale AMoro 1, I-53100 Siena, Italy Univ Siena Viale A Moro 1 Siena Italy I-53100 0 Siena, Italy
Citazione:
M. Csala et al., "Ryanodine receptor channel-dependent glutathione transport in the sarcoplasmic reticulum of skeletal muscle", BIOC BIOP R, 287(3), 2001, pp. 696-700

Abstract

We found that glutathione transport across endo/ sarcoplasmic reticulum membranes correlates with the abundance of ryanodine receptor type 1 (RyR1). The transport was the fastest in muscle terminal cisternae, fast in muscle microsomes and slow in liver, heart, and brain microsomes. Glutathione influx could be inhibited by RyR1 blockers and the inhibitory effect was counteracted by RyR1 agonists. The effect of blockers was specific to glutathione, as the transport of other small molecules was not hindered. Therefore, the glutathione transport activity seems to be associated with RyR1 in sarcoplasmic reticulum. (C) 2001 Academic Press.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 14/07/20 alle ore 09:51:39