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Titolo:
Regulation of cyclo-oxygenase-2
Autore:
Stack, E; Dubois, RN;
Indirizzi:
Vanderbilt Univ, Med Ctr, Dept Med GI, Nashville, TN 37232 USA Vanderbilt Univ Nashville TN USA 37232 pt Med GI, Nashville, TN 37232 USA
Titolo Testata:
BEST PRACTICE & RESEARCH IN CLINICAL GASTROENTEROLOGY
fascicolo: 5, volume: 15, anno: 2001,
pagine: 787 - 800
SICI:
1521-6918(200110)15:5<787:ROC>2.0.ZU;2-F
Fonte:
ISI
Lingua:
ENG
Soggetto:
NONSTEROIDAL ANTIINFLAMMATORY DRUGS; COLON-CANCER CELLS; PROSTAGLANDIN-H SYNTHASE-2; COLORECTAL-CANCER; NITRIC-OXIDE; ALZHEIMERS-DISEASE; ASPIRIN USE; CYCLOOXYGENASE-2 ACTIVITY; GASTROINTESTINAL-TRACT; SELECTIVE-INHIBITION;
Keywords:
arachidonic acid; prostaglandins; eicosanoids; cyclo-oxygenase;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Citazioni:
74
Recensione:
Indirizzi per estratti:
Indirizzo: Stack, E Vanderbilt Univ, Med Ctr, Dept Med GI, MCN C-2104,1161 21st Ave S, Nashville, TN 37232 USA Vanderbilt Univ MCN C-2104,1161 21st Ave S Nashville TN USA 37232
Citazione:
E. Stack e R.N. Dubois, "Regulation of cyclo-oxygenase-2", BEST PR RES, 15(5), 2001, pp. 787-800

Abstract

Over the past three decades studies have been conducted to determine the role of prostaglandins in normal physiology and in certain diseases. Cyclo-oxygenase (COX) or prostaglandin endoperoxide synthase (Pghs) is required for the conversion of arachidonic acid to prostaglandins. Two isoforms of this enzyme have been identified which are referred to as COX-1 and COX-2. Under most circumstances, COX-1 is produced constitutively, whereas COX-2 can be induced by several physiological stimuli and is expressed at sites of inflammation. Although these isozymes catalyze identical reactions, they are often regulated by different signalling systems. The goal of this chapter is to provide a review of the role of cyclooxygenase in biology and disease,and to summarize the current understanding of mechanisms for the regulation of COX-2 expression.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 01/04/20 alle ore 16:02:30