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Titolo:
Epidemiology and differential diagnosis of NSAID-induced injury to the mucosa of the small intestine
Autore:
Smale, S; Tibble, J; Sigthorsson, G; Bjarnason, I;
Indirizzi:
Guys Kings St Thomas Med Sch, Dept Med, London SE5 9PJ, England Guys KingsSt Thomas Med Sch London England SE5 9PJ don SE5 9PJ, England
Titolo Testata:
BEST PRACTICE & RESEARCH IN CLINICAL GASTROENTEROLOGY
fascicolo: 5, volume: 15, anno: 2001,
pagine: 723 - 738
SICI:
1521-6918(200110)15:5<723:EADDON>2.0.ZU;2-4
Fonte:
ISI
Lingua:
ENG
Soggetto:
NONSTEROIDAL ANTIINFLAMMATORY DRUGS; ANTI-INFLAMMATORY DRUGS; MITOCHONDRIAL OXIDATIVE-PHOSPHORYLATION; SMALL-BOWEL ULCERATION; RHEUMATOID-ARTHRITIS; BLOOD-LOSS; DIAPHRAGM DISEASE; GUT HISTOLOGY; RAT JEJUNUM; INDOMETHACIN;
Keywords:
intestinal inflammation; intestinal permeability; inflammatory bowel disease; spondylarthropathy; non-steroidal anti-inflammatory drugs; enteropathy; drug toxicity;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Citazioni:
86
Recensione:
Indirizzi per estratti:
Indirizzo: Bjarnason, I Guys Kings St Thomas Med Sch, Dept Med, Bessemer Rd, London SE5 9PJ, England Guys Kings St Thomas Med Sch Bessemer Rd London England SE5 9PJ
Citazione:
S. Smale et al., "Epidemiology and differential diagnosis of NSAID-induced injury to the mucosa of the small intestine", BEST PR RES, 15(5), 2001, pp. 723-738

Abstract

Non-steroidal anti-inflammatory drugs cause small-bowel inflammation in about 60% of patients receiving these drugs long-term. The inflammation is associated with small intestinal bleeding, protein loss, ulcers and occasionally strictures. Treatment options for NSAID enteropathy include metronidazole, sulphasalazine and misoprostol, and some patients may require surgery. The diagnosis of NSAID enteropathy is not always straightforward. It is especially difficult to differentiate it from the ileitis associated with spondylarthropathy and, at times, that of Crohn's disease. An investigational algorithm is suggested for this purpose. In the last decade a number of small-bowel diseases have been identified, where none were thought to exist, because of the increasing use of enteroscopy and new sensitive tests for intestinal inflammation. Optimal treatmentsof these conditions are still to be studied.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 09/04/20 alle ore 07:50:15