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Titolo:
Epidemiology of NSAID-related gastroduodenal mucosal injury
Autore:
Aalykke, C; Lauritsen, K;
Indirizzi:
Odense Univ Hosp, Dept Gastroenterol, DK-5000 Odense C, Denmark Odense Univ Hosp Odense Denmark C stroenterol, DK-5000 Odense C, Denmark
Titolo Testata:
BEST PRACTICE & RESEARCH IN CLINICAL GASTROENTEROLOGY
fascicolo: 5, volume: 15, anno: 2001,
pagine: 705 - 722
SICI:
1521-6918(200110)15:5<705:EONGMI>2.0.ZU;2-1
Fonte:
ISI
Lingua:
ENG
Soggetto:
NONSTEROIDAL ANTIINFLAMMATORY DRUGS; PEPTIC-ULCER DISEASE; RANDOMIZED CONTROLLED TRIAL; ANTI-INFLAMMATORY DRUGS; SERIOUS GASTROINTESTINAL COMPLICATIONS; HELICOBACTER-PYLORI ERADICATION; RHEUMATOID-ARTHRITIS; ELDERLY PERSONS; RISK-FACTORS; ALCOHOL-CONSUMPTION;
Keywords:
epidemiology; risk factors; non-steroidal anti-inflammatory drugs (NSAIDs); aspirin; drug gastropathy; gastric mucosa; peptic ulcer; stomach; duodenum; peptic ulcer haemorrhage; peptic ulcer perforation; dyspepsia; Helicobacter pylori; number needed to treat;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Citazioni:
91
Recensione:
Indirizzi per estratti:
Indirizzo: Aalykke, C Odense Univ Hosp, Dept Gastroenterol, DK-5000 Odense C, DenmarkOdense Univ Hosp Odense Denmark C , DK-5000 Odense C, Denmark
Citazione:
C. Aalykke e K. Lauritsen, "Epidemiology of NSAID-related gastroduodenal mucosal injury", BEST PR RES, 15(5), 2001, pp. 705-722

Abstract

Non-steroidal anti-inflammatory drugs (NSAIDs) are among the agents most frequently used against musculoskeletal and rheumatic disorders throughout the world. The gastroduodenal adverse effects include dyspepsia without endoscopically proven damage, asymptomatic endoscopic lesions of submucosal haemorrhage, erosions and ulcers, and-most important-ulcer complications. Established risk factors for NSAID-associated ulcer complications include patient-specific factors such as advanced age, female gender, a history of peptic ulcer, and drug-specific factors such as the use of non-selective NSAIDs (type, dose, duration, multiple use) and concomitant anticoagulant drugs orcorticosteroids. Probable risk factors comprise Helicobacter pylori infection and heavy consumption of alcohol, whereas use of selective serotonin re-uptake inhibitors, smoking and a number of other factors have also been proposed to contribute. Knowledge of absolute risk estimates is important forclinical decision making. The aim of this chapter is to summarize the epidemiological data related to the broad spectrum of iatrogenic gastroduodenalmucosal injury.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 25/01/20 alle ore 19:29:43