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Titolo:
How reliable are reported plasma clozapine levels?
Autore:
Bell, R; McLaren, A; Copolov, D;
Indirizzi:
Mental Hlth Res Inst Victoria, Parkville, Vic 3052, Australia Mental Hlth Res Inst Victoria Parkville Vic Australia 3052 052, Australia
Titolo Testata:
AUSTRALIAN AND NEW ZEALAND JOURNAL OF PSYCHIATRY
fascicolo: 4, volume: 35, anno: 2001,
pagine: 468 - 473
SICI:
0004-8674(200108)35:4<468:HRARPC>2.0.ZU;2-4
Fonte:
ISI
Lingua:
ENG
Soggetto:
PERFORMANCE LIQUID-CHROMATOGRAPHY; CLINICAL-RESPONSE; DESMETHYLCLOZAPINE; SCHIZOPHRENIA; EFFICACY;
Keywords:
clozapine; drug monitoring; plasma concentration;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Social & Behavioral Sciences
Clinical Medicine
Citazioni:
22
Recensione:
Indirizzi per estratti:
Indirizzo: Bell, R Mental Hlth Res Inst Victoria, Locked Bag 11, Parkville, Vic 3052,Australia Mental Hlth Res Inst Victoria Locked Bag 11 Parkville Vic Australia 3052
Citazione:
R. Bell et al., "How reliable are reported plasma clozapine levels?", AUST NZ J P, 35(4), 2001, pp. 468-473

Abstract

Objective: Many practitioners use plasma levels to determine the optimum dosage of clozapine. The aim of this study was to determine the intra- and interlaboratory accuracy in assaying samples of clozapine dissolved in humanplasma. Method: Three samples were sent to one laboratory to obtain an initial determination of accuracy (phase I). Then samples of clozapine dissolved in human plasma were prepared at concentrations of 140, 310 and 580 ng/mL and despatched on dry ice to 10 assaying centres in Australia and New Zealand. The results of the survey were analysed and posted to each centre (phase II). The programme was repeated using concentrations of 160, 380 and 640 ng/mL (phase III). Samples prepared in purified water and freeze-dried samples were also despatched. Results: In phase II there were two centres with results significantly different from the mean. In phase III all the centres returned concordant results. There was a high level of consistency in the measurement of samples with a maximum coefficient of variation of 0.16. The concentrations determined by the centres, however, were significantly lower than the nominal concentrations of the prepared solutions. Conclusions: Clinicians in Australia and New Zealand who wish to know their patients' plasma-clozapine levels can be confident that the result of theassay is unlikely to vary with the choice of centre or the operator who performs the assay.

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Documento generato il 29/11/20 alle ore 17:56:20