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Titolo:
Androgen receptor isoforms in human prostatic cancer tissue and LNCaP cellline
Autore:
Xia, SJ; Tang, XD; Ma, QZ;
Indirizzi:
Shanghai First Peoples Hosp, Univ Dept Urol, Shanghai 200080, Peoples R China Shanghai First Peoples Hosp Shanghai Peoples R China 200080 ples R China Shandong Prov Hosp, Univ Dept Urol, Jinan 250021, Peoples R China ShandongProv Hosp Jinan Peoples R China 250021 250021, Peoples R China
Titolo Testata:
ASIAN JOURNAL OF ANDROLOGY
fascicolo: 3, volume: 3, anno: 2001,
pagine: 223 - 225
SICI:
1008-682X(200109)3:3<223:ARIIHP>2.0.ZU;2-7
Fonte:
ISI
Lingua:
ENG
Soggetto:
PHOSPHORYLATION; HETEROGENEITY; SAMPLES; CLONING;
Keywords:
LNCaP cell line; receptors; androgen; phenotype; prostate;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Citazioni:
17
Recensione:
Indirizzi per estratti:
Indirizzo: Xia, SJ Shanghai First Peoples Hosp, Univ Dept Urol, 85 Wu Jin Rd, Shanghai 200080, Peoples R China Shanghai First Peoples Hosp 85 Wu Jin Rd Shanghai Peoples R China 200080
Citazione:
S.J. Xia et al., "Androgen receptor isoforms in human prostatic cancer tissue and LNCaP cellline", ASIAN J AND, 3(3), 2001, pp. 223-225

Abstract

Aim: To investigate the androgen receptor (AR) isoform expressions in human prostatic cancer tissue and LNCaP cell line. Methods: With high resolution isoelectric focusing (IEF) method we demonstrated the different expressions of AR isoforms in human prostatic cancer tissues and LNCaP cell line. Results: Data were obtained from three prostatic cancer specimens and the LNCaP cell line. Three types of AR isoforms were detected with pl values at 6.5, 6.0, and 5.3. For the 3 prostatic cancer specimens, I sample showed all the three types of AR isoforms, the second specimen expressed at 6.5 and 6.0, and the third failed to show any type of isoforms. The LNCaP cell line expressed all the three AR isoforms. Binding of H-3-dihydrotestosterone (H-3-DHT) to these three isoforms was inhibited by the addition of 100-fold excess of DHT or testosterone, while not by progesterone, oestradiol and diethylstilboestrol. Conclusion: The expression of AR isoforms is different in different prostate cancer tissues, which may be related to the difference inthe effect of and-androgen therapy in different patients.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 30/09/20 alle ore 01:29:53