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Titolo:
Correlation of expression of cyclooxygenase-2, vascular endothelial growthfactor, and peroxisome proliferator-activated receptor delta with head andneck squamous cell carcinoma
Autore:
Jaeckel, EC; Raja, S; Tan, J; Das, SK; Dey, SK; Girod, DA; Tsue, TT; Sanford, TR;
Indirizzi:
Univ Kansas, Med Ctr, Dept Otolaryngol Head & Neck Surg, Kansas City, KS 66160 USA Univ Kansas Kansas City KS USA 66160 Neck Surg, Kansas City, KS 66160 USA Univ Kansas, Med Ctr, Dept Physiol, Kansas City, KS 66160 USA Univ KansasKansas City KS USA 66160 t Physiol, Kansas City, KS 66160 USA
Titolo Testata:
ARCHIVES OF OTOLARYNGOLOGY-HEAD & NECK SURGERY
fascicolo: 10, volume: 127, anno: 2001,
pagine: 1253 - 1259
SICI:
0886-4470(200110)127:10<1253:COEOCV>2.0.ZU;2-E
Fonte:
ISI
Lingua:
ENG
Soggetto:
NONSTEROIDAL ANTIINFLAMMATORY DRUGS; COLON-CANCER CELLS; MOUSE UTERUS; PROSTAGLANDINS; PROSTACYCLIN; INHIBITION; IMPLANTATION; PERMEABILITY; PREVENTION;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
32
Recensione:
Indirizzi per estratti:
Indirizzo: Sanford, TR Univ Kansas, Med Ctr, Dept Otolaryngol Head & Neck Surg, 3901 Rainbow Blvd, Kansas City, KS 66160 USA Univ Kansas 3901 Rainbow Blvd Kansas City KS USA 66160 160 USA
Citazione:
E.C. Jaeckel et al., "Correlation of expression of cyclooxygenase-2, vascular endothelial growthfactor, and peroxisome proliferator-activated receptor delta with head andneck squamous cell carcinoma", ARCH OTOLAR, 127(10), 2001, pp. 1253-1259

Abstract

Cyclooxygenase (COX) is the rate-limiting enzyme in the formation of prostaglandins from arachidonic acid. COX exists in 2 isoforms, COX-1 and COX-2. These isoforms are encoded by separate genes and demonstrate cell-specificexpression and regulation. Peroxisome proliferator-activated receptor delta (PPAR delta) is a nuclear transcription factor that is activated by prostacyclin. Vascular endothelial growth factor (VEGF) is a proangiogenic factor that is up-regulated in various tumors. Vascular endothelial growth factor has been shown to interact with COX-derived prostaglandins in angiogenesis. To better understand the roles of these genes in head and neck squamous cell carcinoma (HNSCCA), we examined the differential expression of the COX1, COX2, VEGF, and PPAR delta genes in these tumors. Tissue samples from patients with HNSCCA were analyzed for COX-1, COX-2, VEGF, and PPAR delta messenger RNAs (mRNAs) by in situ hybridization. COX-1 and COX-2 mRNAs were also evaluated with Northern blot hybridization. Immunohistochemistry was used to analyze for COX-2 and PPAR delta proteins. Results showed focal areas of accumulation for COX-2, VEGF, and PPAR delta but not COX-1 in human HNSCCA. Northern blot hybridization showed higher levels of COX-2 mRNA in HNSCCA than in normal tissue. This suggests a supportive role of COX-2 in development and/or progression of HNSCCA. In addition, PPAR delta may be a receptor for COX-2-produced prostaglandins in HNSCCA. There is a potential role for selective COX-2 inhibitors in the treatment of these lesions.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 30/03/20 alle ore 19:47:20