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Titolo:
Therapeutic electrical stimulation of the hypoglossal nerve in obstructivesleep apnea
Autore:
Schwartz, AR; Bennett, ML; Smith, PL; De Backer, W; Hedner, J; Boudewyns, A; Van de Heyning, P; Ejnell, H; Hochban, W; Knaack, L; Podszus, T; Penzel, T; Peter, JH; Goding, GS; Erickson, DJ; Testerman, R; Ottenhoff, F; Eisele, DW;
Indirizzi:
Johns Hopkins Univ, Sch Med, Dept Otolaryngol Head & Neck Surg, Baltimore,MD 21205 USA Johns Hopkins Univ Baltimore MD USA 21205 ck Surg, Baltimore,MD 21205 USA Johns Hopkins Univ, Sch Med, Johns Hopkins Sleep Disorders Ctr, Baltimore,MD 21205 USA Johns Hopkins Univ Baltimore MD USA 21205 ers Ctr, Baltimore,MD 21205 USA Univ Antwerp Hosp, Sleep Ctr, Antwerp, Belgium Univ Antwerp Hosp AntwerpBelgium erp Hosp, Sleep Ctr, Antwerp, Belgium Sahlgrens Univ Hosp, Dept Clin Pharmacol, S-41345 Gothenburg, Sweden Sahlgrens Univ Hosp Gothenburg Sweden S-41345 S-41345 Gothenburg, Sweden Sahlgrens Univ Hosp, Dept Otolaryngol Head & Neck Surg, S-41345 Gothenburg, Sweden Sahlgrens Univ Hosp Gothenburg Sweden S-41345 S-41345 Gothenburg, Sweden Hosp Phillips Univ Marburg, Dept Internal Med, Marburg, Germany Hosp Phillips Univ Marburg Marburg Germany ternal Med, Marburg, Germany Univ Minnesota, Hennepin Cty Med Ctr, Dept Otolaryngol Head & Neck Surg, Minneapolis, MN 55415 USA Univ Minnesota Minneapolis MN USA 55415 k Surg, Minneapolis, MN 55415 USA Medtron Upper Airway, Minneapolis, MN USA Medtron Upper Airway Minneapolis MN USA pper Airway, Minneapolis, MN USA
Titolo Testata:
ARCHIVES OF OTOLARYNGOLOGY-HEAD & NECK SURGERY
fascicolo: 10, volume: 127, anno: 2001,
pagine: 1216 - 1223
SICI:
0886-4470(200110)127:10<1216:TESOTH>2.0.ZU;2-A
Fonte:
ISI
Lingua:
ENG
Soggetto:
UPPER AIRWAY COLLAPSIBILITY; WEIGHT-LOSS; FLOW MECHANICS; NASAL CPAP; UVULOPALATOPHARYNGOPLASTY; PROTRIPTYLINE; PRESSURE; SURGERY; SITE;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
40
Recensione:
Indirizzi per estratti:
Indirizzo: Schwartz, AR 5501 Hopkins Bayview Cir, Baltimore, MD 21224 USA 5501 Hopkins Bayview Cir Baltimore MD USA 21224 MD 21224 USA
Citazione:
A.R. Schwartz et al., "Therapeutic electrical stimulation of the hypoglossal nerve in obstructivesleep apnea", ARCH OTOLAR, 127(10), 2001, pp. 1216-1223

Abstract

Background: Hypoglossal nerve stimulation has been demonstrated to relieveupper airway obstruction acutely, but its effect on obstructive sleep apnea is not known. Objective: To determine the response in obstructive sleep apnea to electrical stimulation of the hypoglossal nerve. Methods: Eight patients with obstructive sleep apnea were implanted with adevice that stimulated the hypoglossal nerve unilaterally during inspiration. Sleep and breathing patterns were examined at baseline before implantation and after implantation at 1, 3, and 6 months and last follow-up. Results: Unilateral hypoglossal nerve stimulation decreased the severity of obstructive sleep apnea throughout the entire study period. Specifically,stimulation significantly reduced the mean apnea-hypopnea indices in non-rapid eye movement (mean +/- SD episodes per hour, 52.0 +/- 20.4 for baseline nights and 22.6 +/- 12.1 for stimulation nights; P<.001) and rapid eye movement (48.2 +/- 30.5 and 16.6 +/- 17.1, respectively; P<.001) sleep and reduced the severity of oxyhemoglobin desaturations. With improvement in sleep apnea, a trend toward deeper stages of non-rapid eye movement sleep was observed. Moreover, all patients tolerated long-term stimulation at night and did not experience any adverse effects from stimulation. Even after completing the study protocol, the 3 patients who remained free from stimulator malfunction continued to use this device as primary treatment. Conclusion: The findings demonstrate the feasibility and therapeutic potential for hypoglossal nerve stimulation in obstructive sleep apnea.

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Documento generato il 18/09/20 alle ore 20:11:34