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Titolo:
Nitric oxide: An unconventional messenger in the nervous system of an orthopteroid insect
Autore:
Bicker, G;
Indirizzi:
Hannover Sch Vet Med, ITZ Cell Biol, D-30559 Hannover, Germany Hannover Sch Vet Med Hannover Germany D-30559 D-30559 Hannover, Germany
Titolo Testata:
ARCHIVES OF INSECT BIOCHEMISTRY AND PHYSIOLOGY
fascicolo: 2, volume: 48, anno: 2001,
pagine: 100 - 110
SICI:
0739-4462(200110)48:2<100:NOAUMI>2.0.ZU;2-B
Fonte:
ISI
Lingua:
ENG
Soggetto:
SOLUBLE GUANYLYL CYCLASE; NADPH-DIAPHORASE HISTOCHEMISTRY; LONG-TERM POTENTIATION; VISUAL-SYSTEM; LOCUST BRAIN; DROSOPHILA-MELANOGASTER; OLFACTORY INTERNEURONS; NEURONAL DEVELOPMENT; PHOTORECEPTOR CELLS; NEURAL ASSEMBLIES;
Keywords:
NO; cGMP; sensory processing; mushroom bodies; motor system; development;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Agriculture,Biology & Environmental Sciences
Life Sciences
Citazioni:
72
Recensione:
Indirizzi per estratti:
Indirizzo: Bicker, G Hannover Sch Vet Med, ITZ Cell Biol, Bunteweg 17D, D-30559 Hannover, Germany Hannover Sch Vet Med Bunteweg 17D Hannover Germany D-30559 many
Citazione:
G. Bicker, "Nitric oxide: An unconventional messenger in the nervous system of an orthopteroid insect", ARCH INS B, 48(2), 2001, pp. 100-110

Abstract

Nitric oxide (NO) is a membrane-permeant messenger molecule generated fromthe amino acid L-arginine. NO can activate soluble guanylyl cyclase leading to the formation of cyclic GMP (cGMP) in target cells. In the nervous system, NO/cGMP signalling is thought to play essential roles in synaptic plasticity during development and also in the mature animal. This paper examines biochemical, cell biological, and physiological investigations of NO/cGMPsignalling in the nervous system of the locust, a commonly used neurobiological preparation. Biochemical investigations suggest that an identical enzyme is responsible for both NO synthase (NOS) and NADPH-diaphorase activityafter tissue fixation. Immunocytochemical staining of an olfactory center in the locust brain shows that NOS-immunoreactivity colocalizes with NADPH-diaphorase at the cellular level. The cytochemical staining of NO donor andtarget cells in adult animals suggests functions in olfaction, vision, andsensorimotor integration. During development, NO is implicated in axonal outgrowth and synaptogenesis. The cellular distribution of NO-responsive cells in neural circuits reflects potential functions of NO as a retrograde synaptic messenger, as an intracellular messenger, and as a lateral diffusible messenger independent of conventional synaptic connectivity. (C) 2001 Wiley-Liss, Inc.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 23/01/20 alle ore 12:28:01