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Titolo:
Are certain diuretics also anticonvulsants?
Autore:
Hesdorffer, DC; Stables, JP; Hauser, WA; Annegers, JF; Cascino, G;
Indirizzi:
Columbia Univ, Gertrude H Sergievsky Ctr, New York, NY 10032 USA Columbia Univ New York NY USA 10032 ergievsky Ctr, New York, NY 10032 USA Columbia Univ, Mailman Sch Publ Hlth, New York, NY 10032 USA Columbia Univ New York NY USA 10032 Sch Publ Hlth, New York, NY 10032 USA Columbia Univ, Dept Neurol, New York, NY 10032 USA Columbia Univ New YorkNY USA 10032 , Dept Neurol, New York, NY 10032 USA Mayo Clin & Mayo Fdn, Dept Hlth Sci Res, Rochester, MN 55905 USA Mayo Clin& Mayo Fdn Rochester MN USA 55905 Res, Rochester, MN 55905 USA Mayo Clin & Mayo Fdn, Dept Neurol, Rochester, MN 55905 USA Mayo Clin & Mayo Fdn Rochester MN USA 55905 urol, Rochester, MN 55905 USA NINCDS, Epilepsy Branch, Preclin Pharmacol Sect, Bethesda, MD 20892 USA NINCDS Bethesda MD USA 20892 eclin Pharmacol Sect, Bethesda, MD 20892 USA Univ Texas, Div Epidemiol, Houston, TX USA Univ Texas Houston TX USAUniv Texas, Div Epidemiol, Houston, TX USA
Titolo Testata:
ANNALS OF NEUROLOGY
fascicolo: 4, volume: 50, anno: 2001,
pagine: 458 - 462
SICI:
0364-5134(200110)50:4<458:ACDAA>2.0.ZU;2-9
Fonte:
ISI
Lingua:
ENG
Soggetto:
ROCHESTER; SEIZURES; MINNESOTA;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
15
Recensione:
Indirizzi per estratti:
Indirizzo: Hesdorffer, DC Columbia Univ, Gertrude H Sergievsky Ctr, 630 W 168th St, New York, NY 10032 USA Columbia Univ 630 W 168th St New York NY USA 10032 0032 USA
Citazione:
D.C. Hesdorffer et al., "Are certain diuretics also anticonvulsants?", ANN NEUROL, 50(4), 2001, pp. 458-462

Abstract

A history of diuretic use has been shown to be protective for first unprovoked seizure in adult patients. Recent animal studies suggest that certain diuretics have anticonvulsant activity. We evaluated the potential for the anticonvulsant activity of current diuretic use in a population-based, case-control study in older adults. We also tested chlorthiazide and furosemidefor seizure protection in animal models of epilepsy. Concurrent medical prescription of any diuretic was protective for the development of epilepsy [odds ratio (OR) = 0.62, 95% confidence interval (CI) = 0.39-0.99]. A protective effect for current thiazide use was observed (OR = 0.53, CI = 0.31-0.90), and a protective effect for furosemide was suggested (OR = 0.44, CI = 0.1-1.9). In mice, both chlorthiazide and furosemide suppressed the occurrence of maximal electroshock-induced seizures in a dose-dependent manner. Chlorthiazide's toxic dose for 50% of animals tested (TD50) could not be achieved even with dosing as high as 1,500mg/kg for furosemide; TD50 was 549 mg/kg. Results were similar in rats. Furosemide and chlorthiazide are protective for unprovoked seizures in an epidemiological study and in animal models. Given the potential therapeutic value for seizure control, low toxicity, and low cost, therapeutic efficacy should be explored in clinical studies.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 02/10/20 alle ore 01:55:16