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Titolo:
Protective effect of 4 ',5-dihydroxy-3 ',6,7-trimethoxyflavone from Artemisia asiatica against A beta-indueed oxidative stress in PC12 cells
Autore:
Heo, HJ; Cho, HY; Hong, BS; Kim, HK; Kim, EK; Kim, BG; Shin, DH;
Indirizzi:
Korea Univ, Grad Sch Biotechnol, Seoul 136701, South Korea Korea Univ Seoul South Korea 136701 iotechnol, Seoul 136701, South Korea Hanseo Univ, Dept Food & Biotechnol, Seosan 356820, South Korea Hanseo Univ Seosan South Korea 356820 echnol, Seosan 356820, South Korea Inha Univ, Dept BIol Engn, Inchon 402751, South Korea Inha Univ Inchon South Korea 402751 Iol Engn, Inchon 402751, South Korea Seoul Natl Univ, Dept Genet Engn, Seoul 151742, South Korea Seoul Natl Univ Seoul South Korea 151742 Engn, Seoul 151742, South Korea
Titolo Testata:
AMYLOID-JOURNAL OF PROTEIN FOLDING DISORDERS
fascicolo: 3, volume: 8, anno: 2001,
pagine: 194 - 201
SICI:
1350-6129(200109)8:3<194:PEO4''>2.0.ZU;2-V
Fonte:
ISI
Lingua:
ENG
Soggetto:
AMYLOID PRECURSOR PROTEIN; BROMIDE MTT REDUCTION; ALZHEIMERS-DISEASE; HIPPOCAMPAL-NEURONS; IN-VITRO; NEUROTOXICITY; DEATH; TOXICITY; PEPTIDE; AGGREGATION;
Keywords:
4 ',5-dihydroxy-3 ',6,7-trimethoxyflavone; Artemisia asiatica; amyloid-beta protein; oxidative stress; Alzheimer's disease;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
43
Recensione:
Indirizzi per estratti:
Indirizzo: Shin, DH Korea Univ, Grad Sch Biotechnol, Seoul 136701, South Korea Korea Univ Seoul South Korea 136701 , Seoul 136701, South Korea
Citazione:
H.J. Heo et al., "Protective effect of 4 ',5-dihydroxy-3 ',6,7-trimethoxyflavone from Artemisia asiatica against A beta-indueed oxidative stress in PC12 cells", AMYLOID, 8(3), 2001, pp. 194-201

Abstract

Amyloid beta protein (A beta)-induced free radical-mediated neurotoxicity is a leading hypothesis as a cause of Alzheimer's disease (AD). A beta increased free radical production and lipid peroxidation in PC12 nerve cells, leading to apoptosis and cell death. The effect of 4',5-dihydroxy-3',6,7-trimethoxyflavone from Artemisia asiatica on A beta induced neurotoxicity was investigated using PC12 cells. Pretreatment with isolated 4',5-dihydroxy-3',6,7-trimethoxyflavone and vitamin E prevented the A beta -induced reactiveoxygen species (ROS). The 4',5-dihydroxy-3,6,7-trimethoxyflavone resulted in concentration-dependant decreased A beta toxicity assessed by 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide (MTT) assay. However, treatment with these antioxidants inhibited the A beta -induced neurotoxic effect. Therefore, these results indicate that micromolecular A beta -inducedoxidative cell stress is reduced by 4',5-dihydroxy-3',6,7-trimethoxyflavone from Artemisia asiatica.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 20/01/20 alle ore 15:56:44