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Titolo:
Effects of budesonide and formoterol on NF-kappa B, adhesion molecules, and cytokines in asthma
Autore:
Wilson, SJ; Wallin, A; Della-Cioppa, G; Sandstrom, T; Holgate, ST;
Indirizzi:
Univ Southampton, Sch Med, Resp Cell & Mol Biol Res Div, Southampton, Hants, England Univ Southampton Southampton Hants England , Southampton, Hants, England Univ Hosp No Sweden, Umea, Sweden Univ Hosp No Sweden Umea SwedenUniv Hosp No Sweden, Umea, Sweden Novartis, Horsham Res Ctr, Horsham, W Sussex, England Novartis Horsham W Sussex England am Res Ctr, Horsham, W Sussex, England
Titolo Testata:
AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE
fascicolo: 6, volume: 164, anno: 2001,
pagine: 1047 - 1052
SICI:
1073-449X(20010915)164:6<1047:EOBAFO>2.0.ZU;2-F
Fonte:
ISI
Lingua:
ENG
Soggetto:
TRANSCRIPTION FACTOR; AIRWAY INFLAMMATION; GLUCOCORTICOID RECEPTOR; BRONCHIAL-MUCOSA; MAST-CELLS; ACTIVATION; EXPRESSION; SALMETEROL; EOSINOPHILS; MECHANISMS;
Keywords:
budesonide; formoterol; NF-kappa B; immunohistochemistry; asthma;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
35
Recensione:
Indirizzi per estratti:
Indirizzo: Wilson, SJ Southampton Gen Hosp, Mailpoint 810,Ctr Block,Level D,Tremona Rd, Southampton SO16 6YD, Hants, England Southampton Gen Hosp Mailpoint 810,Ctr Block,Level D,Tremona Rd Southampton Hants England SO16 6YD
Citazione:
S.J. Wilson et al., "Effects of budesonide and formoterol on NF-kappa B, adhesion molecules, and cytokines in asthma", AM J R CRIT, 164(6), 2001, pp. 1047-1052

Abstract

The asthmatic inflammatory response can be attenuated by corticosteroids and in part by beta (2)-agonists. We investigated if these effects are accompanied by a downregulation in nuclear factor kappa B (NF-kappaB), a transcription factor regulating many of the cytokine and adhesion molecule genes expressed in allergic inflammation. Bronchial biopsies were taken before andafter 8 wk treatment with formoterol, budesonide, or placebo from atopic asthmatics. Biopsies were processed into glycol methacrylate and stained immunohistochemically for eosinophils (as an index of inflammation), activatedand total NF-kappaB, adhesion molecules, and cytokines. After budesonide treatment there was a significant decrease in the number of submucosal cellsstaining for total NF-kappaB, granulocyte macrophage colony-stimulating factor (GM-CSF) and tumor necrosis factor-alpha (TNF-alpha), accompanied by asignificant decrease in mucosal eosinophils and expression of vascular cell adhesion molecule-1 (VCAM-1) in the endothelium and interleukin-8 (IL-8) in the epithelium. After formoterol treatment there was a significant decrease in eosinophils and the epithelial expression of activated NF-kappaB, but these changes were not accompanied by reduced immunoreactivity for adhesion molecules or cytokines. We conclude that at least some of the therapeutic efficacy of inhaled corticosteroids is mediated through inhibition of NF-kappaB-regulated gene expression, whereas the reduction in airway eosinophilia by long-acting beta (2)-agonists probably operates through alternative pathways.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 25/01/20 alle ore 19:12:31